Class notes

Biology 2 - Unit 1 Notes

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Course
BIOSC 0160

Institution
University Of Pittsburgh - Pittsburgh

Some notes I took during unit 1 lectures with Nathan Brouwer. His slides can be confusing and long, so these notes highlight almost everything important, so you don't have to spend hours relooking through his slides (like I did).

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Uploaded on August 2, 2024
Number of pages 2
Written in 2023/2024
Type Class notes
Professor(s) Nathan brouwer
Contains Biology 2 - unit 1

biology 2
bio 2
dna
dna replication
okazaki fragments
pcr
nucleotides
nucleosides
phenotypes
phenotype
genotypes
genotype
phenotypes vs genotypes
chromosomes
gwas
gene wide
nucleotides vs nucleotides

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*Chr4:21338700 < -This is a Genomic Address
For each chromosome, a starting point is established-
Units are nucleotides ~2 million nucleotides into the gene ○-
DNA is a unique molecule with a unified relationship between structure and function DNA structure includes its:
chemistry ○
Subunits ○
Polarity (directionality, eg 5' 3') ○
Stoichiometry (ratio of subunits)○
1D, 2D, 3D appearance ○-
Primary Structure
The one dimensional structure of a molecule -
Cares more about the sequence rather than the appearance -
Secondary, Tertiary, Quaternary…-
DNA is a unique molecule with a unified relationship between structure and function
The structure of a molecule doesn’t immediately explain how it works -
Not the case with DNA, DNA immediately suggested how it could carry information and how it could reproduce itself -
DNA function is about information Stores information-
Maintains information-
Expresses information -
Transmitting information-
Be configured and rewritten -
Doesn’t do all of these things on its own but it creates the environment in which these things can happen Proteins bind to the major and minor groove of DNA Adenine Guanine
Thymine
Cytosine
Uracil DNA Structure: H bonds, Van der Waals, etc. Double Stranded DNA (dsDNA) Naturally takes the shape of a double helix 3 dimensional curve -
The 2 strands are held together by hydrogen bonds G and C are held by 3 bonds○
T and A are held by 2 bonds ○-
Van der Waals forces When G,T,A,C are stacked next to each other in the molecule -DNA: Overview of Structure and Function Tuesday, January 16, 2024 9:29 AM New Section 1 Page 1

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