Camilla Franklin I Human Case Study 48- year-old With Fatigue & Irritability Week 10 Screenshots August 2024 With Correct Question And Answers Graded A+

Camilla Franklin I Human Case Study 48- year-old With Fatigue & Irritability Week 10 Screenshots August 2024 With Correct Question And Answers Graded A+ What causes Celiac disease? Ms. Schilling case - ANSWER-Stress or infection and genetic susceptibility leads to a inflammatory milieu leading to increased antigen sampling. Higher levels of TNF and IL-15 (can turn into natural killer cells in high amounts). HLA positive is driving force then more non-HLA genes cause more or less vulnerability. Genes related to Celiac disease Ms Schilling case - ANSWER-HLA-DQ2 HLA-DQ8 on chromosome 6 but other factors important because 40% of population has these variants, not a great screening test. 64 other associated genes in Celiac. 40 of these genes interact with each other and influence TNF and IL-15 Clues about the patient's stool for Ms. Schilling - ANSWER-If floating high fat content, if watery the colon is not able to absorb water, urgency also indicates more water in stool Role of the gallbladder for Ms. Schilling - ANSWER-Patient had gallstones, gallbladder is responsible for making bile so could be recurrence of gallstones. Gallstones can be stuck in gallbladder and often in the sphincter of Oddi area. This could be the reason for her pain. Differential diagnoses for Ms. Schilling - ANSWER-Gluten sensitivity, gallstones, irritable bowel syndrome, pancreatitis maybe (but usually related to alcohol use), substance abuse--possibly laxative abuse in this case, ulcerative colitis, anxiety/stress, cancer, giardiasis (from contaminated water) Significant findings for Ms. Schilling - ANSWER-Low albumin (protein) levels (malabsorption), gall stones were present but no signs of inflammation, macrocytic anemia due to low vitamin B12 (malabsorption), positive for glandin IgA and glandin IgG antibodies (Celiac), positive endomysial Ab screen (Celiac) Findings which support Ms. Schilling's diagnosis - ANSWER-Diarrhea (with fecal fat) associated with abdominal pain worsened with wheat products, weight loss due to malabsorption, positive antibodies for gliadin and endomysium, to confirm diagnosis obtain biopsy of small intestine via endoscopy (will show flat mucosal villi surface with plasmacytic infiltration of subepithelial region), coagulopathy (deficiencies) 5 complications specific to Celiac disease for Ms. Schilling - ANSWER-1. Malnutrition: if left untreated, happens in spite of adequate diet, deficiency in vitamins/minerals, vitamin D, folate, iron, anemia, weight loss 2. Loss of calcium and bone density: loss of fat in stool causing calcium and vitamin D loss, may result in osteomalacia, osteoporosis 3.