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SBCP - Pharmacokinetics Exam Study Guide
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SBCP - Pharmacokinetics Exam StudyGuide
The Barriers across - Answer Direct penetration of lipid membrane
Diffusion through aqueous pores
Transporters (influx and efflux)
ADMET is: - Answer Absorption: Entry into body
Distribution: to the stire of action
Metabolism: chemical changes
Elimination: removal from body
Toxicity: effect other than desired
Enteral 1 Via the intestines - Answer - most common, safe and cheapest
- absorbed from stomach and intestines
- must past trhough liver before getting to systemic circulation
- Rates of absorption depends on formulation
Enteral 1 (oral) - Answer Tablet --> molecules --> Drug in solution in GIT --> liver (small %
metabolised) --> Hepatic Vein --> The Systemic circulation --> Hepatic Artery -->GIT
Enteral 2 methods are: - Answer Sublingual
Rectal
sublingual route - Answer · Rapid absorption from under tongue
· Directly into systemic circulation
· E.g. GTN for angina pain
Rectal Route - Answer · Useful if person is vomiting or unconscious
· 50% of absorbed drug will bypass the liver
· Absorption is often irregular and incomplete
· E.g. antiemetics
Parenteral (outside the Intestines) 1 route are: - Answer Intra-venous
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