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Nuclear Medicine Board Exam Review 10 a Questions and Answers
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hat is blood brain barrier (BBB) imaging used for? Ans- determine cerebral brain death (usually planar imaging if the patient is claustrophobic or needs to be done at the bedside) what are the indications to preforming BBB planar brain imaging? Ans- 1) primary metastatic disease ( glioma, meni...

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  • August 3, 2024
  • 26
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • nuclear medicine board exam review 10 a questions

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  • Nuclear Medicine Board
  • Nuclear Medicine Board

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Nuclear Medicine Board
Exam Review 10 a
Questions and Answers


what is blood brain barrier (BBB) imaging used for?


Ans- determine cerebral brain death (usually planar imaging if the patient is

claustrophobic or needs to be done at the bedside)




what are the indications to preforming BBB planar brain imaging?


Ans- 1) primary metastatic disease ( glioma, meningioma)


2)intracranial inflammatory disease (abscess, encephalitis)


3)cerebral vascular disease (hemorrhage, vascular occlusion, hemangioma)


4)complications of head trauma

,what is the blood brain barrier and why under normal circumstances would a

radiopharmaceutical not cross it?


Ans- defense that prevents undesired substances from reaching the brain or

the CSF.




under normal circumstances when the BBB is intact, radiotracers would not be

able to cross, but where it is damaged, the tracer is able to cross




what is the desired radiopharmaceutial for BBB imaging and why?


Ans- 99mTc-pentetate (DTPA) is desired due to the rapid clearance by the

kidneys which leads to a higher target to non target ratio




what radiopharmaceutical is not desired for BBB imaging and why?


Ans- 99mTc-pertechnetate because it has an increased uptake in the choroid

plexus so you would need to administer a blocking agent prior (potassium

perchlorate)

, what is the primary PET imaging agent for BBB imaging? what does its uptake

levels in the brain mean?


Ans- 18F-FDG




concentration in the tumor=hotter


no concentration in the tumor=cold




is there any special patient prep needed for a BBB imaging study?


Ans- no special prep




get a patient history and if using pertechnetate use the blocking agent (0.2-1g

potassium perchnorate)




what is the protocol for imaging of the BBB?


How much tracer?


Ans- almost always planar


3-phase study

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