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Lehne-s Pharmacology Exam 1 Ch 1-6 questions with answers 2024 $14.49   Add to cart

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Lehne-s Pharmacology Exam 1 Ch 1-6 questions with answers 2024

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Lehne-s Pharmacology Exam 1 Ch 1-6 questions with answers 2024

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  • August 4, 2024
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  • Lehne's Pharmacology
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Lehne's Pharmacology Exam 1 Ch 1-6
questions with answers 2024

Pharmacokinetics mm- mmANSWER: mm mm➡ mmThe mmprocess mmby mmwhich mmdrugs mmare mmabsorbed,
mmdistributed mm, mmmetabolized, mmand mmexcreted.




Absorption mm- mmANSWER: mm mm➡ mmdetermines mmintensity mm& mmtime mmof mmthe mmeffects



3 mmways mmto mmcross mma mmcell mmmembrane mm- mmANSWER: mm mm➡ mm- mmchannels mmand
mmpores(electrolytes/ions)



- mmtransport mmsystems mm(P-glycoprotein)

- mmdirect mmpenetration mmof mmthe mmmembrane(lipid mmsoluble)



blood-brain mmbarrier mm- mmANSWER: mm mm➡ mmBlood mmvessels mm(capillaries) mmthat mmselectively
mmlet mmcertain mmsubstances mmenter mmthe mmbrain mmtissue mmand mmkeep mmother mmsubstances mmout




Routes mmof mmDrug mmAdministration: mm- mmANSWER: mm mm➡ mmParenteral-(via mminjection)

Intravenous, mmintramuscular, mmsubcutaneous mm(SC)

Enteral/Oral- mmby mmmouth



drug mmmetabolization mm- mmANSWER: mm mm➡ mmstructural mmenzyme mmchange



P450 mmsystem mm(cytochrome mmP450) mm- mmANSWER: mm mm➡ mmox mmenzymes: mmdetoxify, mmimproves
mmsolubility mmto mmbe mmexc mmby mmkidneys mm(12 mmenzyme mmfamilies)




What mmenzymes mmof mmCytochrome mmP450 mmmetabolize mmdrugs? mm- mmANSWER: mm mm➡ mmCYP
mm1,2,3

,What mmare mmtherapeutic mmconsequences mmof mmmetabolism? mm- mmANSWER: mm mm➡ mmAccelerated
mmrenal mmsecretion



Drug mminactivation

increased mmtherapeutic mmaction

Activation mmof mmpro mmdrugs

increased mmor mmdecreased mmtoxicity



Prodrugs mmare mm- mmANSWER: mm mm➡ mminactive mmand mmmust mmbe mmmetaboliz/activated mmin mmthe
mmliver




Considerations mmfor mmdrug mmmetabolism mm- mmANSWER: mm mm➡ mmAge-induction& mminhibition mmof
mmdrug mmmetabolizing mmenz




Faster mmmetabolization mmof mma mmdrug mm=____ mm- mmANSWER: mm mm➡ mmneed mma mmhigher mmdosage



Induction mmof mmmetabolic mmenzymes mm- mmANSWER: mm mm➡ mmstimulating mmenzyme mmsynthesis



drug mmexcretion mm- mmANSWER: mm mm➡ mmthe mmprocess mmof mmeliminating mmmedications, mmusually
mmthrough mmthe mmkidneys mmin mmurine, mmbut mmalso mmthrough mmsweat, mmfeces, mmand mmsaliva, mmmilk

mmproduction




kidney mmexcretion mm- mmANSWER: mm mm➡ mm-blood mmis mmfiltered mmthrough mmthe mmglomerulus mmof
mmthe mmkidneys



-molecules mmthat mmare mmsufficiently mmpolar mmfrom mmmetabolism mmwill mmbe mmexcreted mmout mmof
mmthe mmnephron



-those mmthat mmare mmstill mmnot mmpolar mmenough mmwill mmbe mmre-absorbed mmback mminto mmthe
mmblood




Active mmtubular mmsecretion mm- mmANSWER: mm mm➡ mmactive mmtransport mmsystems mmin mmthe mmrenal
mmtubule mmwork mmto mmmove mmsome mmdrugs mmfrom mmthe mmblood mmand mminto mmthe mmurine mm(Acids

mmand mmbases)

, passive mmtubular mmreabsorption mm- mmANSWER: mm mm➡ mmdrugs mmthat mmare mmlipid-soluble
mmundergo mmpassive mmreabsorption mmfrom mmthe mmtubule mmback mminto mmthe mmblood



Polar mmand mmionized mmstay mmin mmurine



glomerular mmfiltration mm- mmANSWER: mm mm➡ mmexcretes mmdrugs mmin mmurine

protein mmbound mmdrugs mmare mmnot mmfiltered



Pharmacodynamics mm- mmANSWER: mm mm➡ mmwhat mmthe mmdrug mmdoes mmto mmthe mmbody



dose-response mmrelationship mm- mmANSWER: mm mm➡ mmthe mmrelationship mmbetween mmthe
mmdifferent mmdoses mmand mmthe mmresponses mmthey mmgenerate




What mmdo mmdose mmresponse mmrelationships mmdetermine? mm- mmANSWER: mm mm➡ mmminimum
mmeffective mmdoes



maximum mmresponse mmelicited

how mmto mmincrease mmdosage mmto mmdesired mmresponse



relative mmpotency mm- mmANSWER: mm mm➡ mmthe mmamount mmof mmdrug mmthat mmmust mmbe mmgiven mmto
mmelicit mman mmeffect




Potency mmvs mmEfficacy mm- mmANSWER: mm mm➡ mmpotency: mmamount mmof mmdrug mmnecessary mmto
mmproduce mmeffect(conc)



efficacy: mmability mmof mmdrug mmto mmachieve mmdesired mmeffect



Because mmmorphine mmis mmmore mmpotent mmthan mmmeperidine, mmis mmit mma mmbetter mmdrug? mm-
mmANSWER: mm mm➡ mmno. mmYou mmneed mmless mmto mmachieve mmthe mmsame mmresult.




Receptor mm- mmANSWER: mm mm➡ mmDRUG mmBINDS mmHERE

on mmor mmin mma mmcell, mma mmspecific mmprotein mmto mmwhose mmshape mmfits mmthat mmof mma mmspecific
mmmolecular mmmessenger, mmsuch mmas mma mmhormone

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