Exam (elaborations)
MRCP Part 1 QUESTIONS AND ANSWERS 2024
- Course
- Institution
MRCP Part 1 QUESTIONS AND ANSWERS 2024
[Show more]
Content preview
MRCP Part 1 QUESTIONS AND ANSWERS2024
Pregnancy and Thyroid Hormone - Pregnancy increases the amount of TBG
(thyroid binding globulin) so increases the total thyroxin levels but not free
thyroxine
Hyperthyroid in pregnancy - Untreated - fetal loss, premature labour, maternal
heart failure
Graves disease most common
HCG can activate TSH receptors - transient gestational hyperthyroid - these fall in
trimester 2 & 3
treatment - propylthiouracil in first trimester
this can cause hepatic injury
carbimazole in 2nd trimester once lower risk of congenital abnormalities
Monitoring - free thyroxine levels should be kept upper third normal so to avoid
fetal hypothyroid
- thyrotrophin receptor stimulating antibodies should be checked weeks 30-36
DO NOT - block and replace or use radioiodine.
Hypothyroid in pregnancy - Thyroxine replacement is safe in pregnancy and
breastfeeding
TSH measured each trimester and 6-8 weeks post partum
,MRCP Part 1 QUESTIONS AND ANSWERS
2024
Women often require an increased dose - up to 50% by weeks 4-6
untreated - developmental abnormalities, miscarriage, still birth, low birth weight,
pre-eclampsia, anaemia
Gentamicin - Aminoglycoside antibioitic
Given IV or topically
Ototoxic - irreversible due to auditory or vestibular nerve damage
Nephrotoxic - causes tubular necrosis, accumulates in renal failure requiring
increased monitoring, furosemide increases this risk
CI - Myasthenia Gravis
Dosed via height and weight and renal function. Peak and trough levels monitored
with dose adjustments based on trough levels
CSF: Protein levels - normal = 0.2-0.4 g/L
Causes of raised CSF protein
GBS
Froin's syndrome - a spinal canal blockage characterised by xanthochromia, raised
protein and CSF hypercoagulability
TB, bacterial or fungal meningitis
,MRCP Part 1 QUESTIONS AND ANSWERS
2024
viral encephalitis
Vigabatrin - Irreversibly inhibits GABA transaminase-->increased GABA levels in
synapse
Uses = tx infantile spasms (Viga"Baby"trin)
Or used as adjunct therapy for adults with refractory complex partial seizures
SE = visual field constriction and even visual loss in 40% of patients- visual fields
must be checked every 6 months as visual loss can be irreversible
Tricuspid regurgitation - Signs: pansystolic murmer, parasternal heave, giant V
waves, pulsatile hepatomegaly
causes: IVDU endocarditis, rheumatic heart disease, right ventricle infarction,
pulmonary hypertension, carcinoid syndrome, epsteins anamoly (rare heart defect
that causes tricuspid regurg)
Corticosteroid side effects - COME IN PIGG
, MRCP Part 1 QUESTIONS AND ANSWERS
2024
Cushings
opthalmic - glaucoma, catterachts
M - musculoskeletal - OP, proximal myopathy, avascular necrosis
Endocrine- hyperglycaemia, weight gain, hirsuitism, high lipids
Immunosupression
Neutrophilia
Psychiatric - mania, psychosis, insomnia, depression
Intracranial hypertension
Gastric - pancreatitis, ulcers,
Growth suppression in kids
Acne - Systemic glucocorticoids can cause drug-induced acne. This is characterised
as monomorphic papular rash without comedones or cysts. This does not respond
to acne treatment but improves on drug discontinuation
Therapeutic Steroids - Fludocortisone - mostly mineralocorticoid
hydrocortisone - some glucocorticoid, some mineralocoticoid
Dexamethsone - high glucocorticoid
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Ellah1. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
73091 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now