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Pharm: ANDROGENS Exam Questions and Answer
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Pharm: ANDROGENS Exam Questions and Answer
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Pharm: ANDROGENS Exam Questionsand Answer
What are the 3 androgens? -
correct answer ✅include testosterone, androstenedione, and
dehydroepiandrosterone (DHEA).
Where is testosterone produced? -
correct answer ✅Testosterone is produced by the Leydig cells of the
testis, the adrenal glands, and the theca cells of the ovary (women).
Where does 5-alpha dihydrotestosterone (DHT) come from? -
correct answer ✅Testosterone is metabolized to 5-alpha
dihydrotestosterone (DHT) *in the prostate*. Whereas in other tissues
such as the muscle or kidney it remains unchanged.
What is the most potent androgen? -
correct answer ✅a. DHT is the most potent androgen required for sex
development.
b. It is synthesized from testosterone in the prostate gland, testes, hair
follicles, and adrenal glands by *5-alpha reductase*
c. DHT is the ESSENTIAL androgen in the prostate and is therefore the
main hormonal driver of prostatic cancer
What is the pathway by which the adrenal glands will be stimulated to
produce androgens? -
correct answer ✅The *hypothalamus* secretes *corticotropin-
releasing hormone*, which acts on the pituitary to secrete
, Pharm: ANDROGENS Exam Questions
and Answer
*adrenocorticotropin (ACTH)*, which acts on the adrenal cortex to
secrete glucocorticoids, mineralocorticoids, and androgens (5% of
testosterone is formed in this pathway).
*Androgens are a product of the adrenal cortex, however, they are not
the major product, corticosteroids are.*
What is SHBG and where does it come from? -
correct answer ✅SHBG is a large serum glycoprotein derived from the
LIVER.
-->If a person has a liver problem they can often have decreased levels
of SHBG and increased free testosterone levels.
-->SHBG is a strong binder of testosterone.
-->Levels of SHBG are *increased* by *estrogens (females have 2-3
times more SHBG than males) and thyroxine*.
-->Levels of SHBG are *decreased* by *androgens, growth hormone,
and insulin*.
------If you decrease the levels of SHBG you have more androgens
present; Growth hormone is sometimes taken by athletes to increase
performance
What is responsible for the conversion of progesterone to
androstenedione? -
correct answer ✅P450 - can impact medications
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