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Immunodeficiency’s Exam – Questions With Solutions
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Immunodeficiency’s Exam – Questions With Solutions
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Immunodeficiency’s Exam – Questions With SolutionsWhich primary immunodeficiency mainly impacts B cell development without
affecting T cells? Right Ans - X-linked agammaglobulinemia (XLA)
Individuals with X-linked agammaglobulinemia (XLA) are more susceptible to
some kinds of pathogens than others. What pathogen do you think an XLA
patient would be LEAST susceptible to? Right Ans - intracellular bacterium
M. tuberculosis is the only intracellular pathogen listed in the answers above.
XLA is a deficiency of antibodies, which function almost exclusively outside of
cells. Individuals with XLA have an increased frequency of S. aureus, S.
pneumoniae, and G. lamblia infections. XLA patients are more susceptible to
mycobacterial infections, but these infections are much less frequent in XLA
patients than infections with the other pathogens listed above.
The number of B lymphocytes and T lymphocytes in the blood is an important
component of the clinical diagnosis of primary immunodeficiencies. Which
disorder would be most likely to lead to low blood counts of T cells and B
cells? Right Ans - RAG type SCID
Which of these factors does NOT contribute to the generation of self-reactive
T cells? Right Ans - millions of different inherited T cell receptor genes
Which of the following is a mechanism of peripheral tolerance that controls
self-reactive effector B cells AND self-reactive effector T cells? Right Ans -
regulatory T cell suppression
What is the main difference between central tolerance in the thymus and in
the bone marrow? Right Ans - Clonal deletion of T cells occurs in the
thymus, while receptor editing of B cells occurs in the bone marrow. correct
How do antibodies contribute to glomerulonephritis in lupus? Right Ans -
Antibodies form immune complexes, which cause inflammation that damages
kidney vessels. correct
How do antibodies contribute to myasthenia gravis? Right Ans - Antibodies
neutralize a key molecule involved in neuron function
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