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Exam (elaborations)

Pharmacology Exam 1: Questions & Accurate Solutions

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  • Course
  • HMX Pharmacology
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  • HMX Pharmacology

Pharmacology Exam 1: Questions & Accurate Solutions

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  • August 8, 2024
  • 19
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • HMX Pharmacology
  • HMX Pharmacology
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LeCrae
Pharmacology Exam 1: Questions & Accurate Solutions

Alprazolam Right Ans - Xanax

Methylenedioxymethamphetamine (MDMA) Right Ans - ecstasy

Diazepam Right Ans - Valium

Aceteminophen Right Ans - Tylenol

Lorazepam Right Ans - Ativan

Phenobarbital Right Ans - Luminal

Benzodiazepines Right Ans - -pam, -lam, -barbital endings

Levothyroxine Right Ans - Synthroid

Glasdegib Right Ans - Daurismo
-treats AML

Becavizumab Right Ans - Avastatin
-treats recurrent glioblastoma

Gabapentin Right Ans - Neurontin
-treats chronic pain

Fluoxetine Right Ans - Prozac
-treats depression and chronic pain (SSRI)

Omeprazole Right Ans - Prilosec
-treats GI issues

Pseudoephedrine Right Ans - Sudafed
-used by crackheads

Atropine Right Ans - Motofen

,Pregabalin Right Ans - Lyrica

Lisdexamfetamine Right Ans - Vyvanse

ED50 Right Ans - Effective dose in 50% of the population

EC50 Right Ans - Concentration of the drug that produces 50% of maximal
effect in one person

TD50 Right Ans - toxic dose in 50% of the population

LD50 Right Ans - lethal dose for 50% of the population

TI (therapeutic index) Right Ans - the ratio of the amount of drug to
produce a therapeutic dose compared with the amount of drug that produces
a lethal dose; the farther apart the ED and the TD the safer the drug

The graph above shows the dose-response curves for the therapeutic and
toxic effects of a new drug (Drug B) in a group of individuals compared to a
standard of care drug that is currently being prescribed to patients (Drug A).
Both drugs are tested in the same group of individuals. For Drug B, the
therapeutic index is _______ than that of Drug A, meaning that adverse effects
produced by the drug will occur at ______ doses compared to Drug A. Right
Ans - smaller; smaller

Ideally drugs will be both effective and safe. Penicillin, for example, is an
antibiotic used to treat infections caused by susceptible bacteria, and is
virtually nontoxic even in large doses (except for people who are allergic to
it). This means that penicillin has a very ____________ value.

A) high TD50
B) high ED50
C) Low TD50
D) Low ED50 Right Ans - A

biotransformation Right Ans - chemical changes that take place in the drug
following administration

, Metabolism Right Ans - the chemical transformation of a drug to a
metabolite

Excretion Right Ans - the removal of a drug and its metabolites from the
body

Absorption Right Ans - movement of the drug into the bloodstream after
administration

Bioavailability Right Ans - the rate at and the extent to which a nutrient is
absorbed and used
-if there are more barriers for the drug to cross, the bioavailability will be
lower

Distribution Right Ans - delivering a drug from the bloodstream to the
tissues of the body

Prodrug Right Ans - An inactive drug dosage form that is converted to an
active metabolite by various biochemical reactions once it is inside the body.

Prodrugs (increase/decrease) bioavailability? Right Ans - increase

polar drugs are excreted
(true or false) Right Ans - true

facilitated diffusion Right Ans - process of diffusion in which molecules
pass across the membrane via a carrier molecule, this does not require any
energy expenditure

nonpolar drugs are excreted
(true or false) Right Ans - false, are reabsorbed and stay in system longer

Passive diffusion is when a drug travels across the cell membrane from an
area of ____________ concentration to an area of ____________ concentration.

A)high; high
B)high; low
C)Low; high

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