And Answers
What are the physiologic changes of a geriatric patient?
✓~ reduction in total body water and lean body mass
increase in body fat
reduction in kidney and liver mass and function
reduction in process that maintains equilibrium
What affects absorption in a geriatric patient?
✓~ GI changes
decrease in bowel surface area
slowed gastric emptying
decrease gastric blood flow
decrease swallowing ability
decreased nutrition
, What affects distribution in geriatric patients?
✓~ decrease in muscle mass an increase in fat in patients so LIPID SOLUBLE
DRUGS HAVE INCREASED DISTRIBUTION AND DECREASED
ELIMINATION
decrease in albumin so increase in free drugs
increase in therapeutic effects as well as drug toxicity
What affects metabolism in geriatric patients?
✓~ decreased hepatic blood flow
deceased first pass metabolism
increased half life
What affects excretion in geriatric patients?
✓~ decreased renal excretion resulting in prolonged half life and elevated drug levels
What affects the pharmacodynamics in geriatric patients?