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Case 6
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Case 6 of BBS1001. Goes in bundle together
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By: segercramers • 3 year ago
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Case 6Learning goals:
1. Protein transporting (folding/misfolded, sorting/labelling,
transport/pathways)
2. What are the destinations of proteins and how do they get there?
3. Explain the two diseases
, 1. Protein transport
Gated transport
Transport through the membranes of an organelle.
Bijv. through the pores of the nucleus.
Small molecules can go through the nucleus without any help. But large
molecules are helped by an import receptor and by Ran-GTP and Ran-
GDP.
Transmembrane transport (doesn’t go through ER)
Transport for proteins into the mitochondria.
First the proteins need to go through the outer membrane going
through the TOM complex. After that, it goes through the second
membrane going through the TIM23 complex. And then it goes into
the matrix.
A protein can only pass these complexes when it has a special sequence
of positive amino acids in the N-terminus. After passing it, the sequence
gets cut off.
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