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The Chimp and the River (1)
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The Chimp and the RiverGaetan Dugas
-many of the patients were tried back to this person (2500)
-flight attendant : lots of travel
-once diagnosed some suggested that he intentionally transmitted the disease - ANS-Patient
zero
- can lead to acquired immunodeficiency syndrome or AIDS if not treated
-unlike some other viruses, the human bod can't rid of HIV completely, even with treatment
-once get it, have it for life - ANS-HIV (human immunodeficiency Virus)
-CD4 cells (t-cells)
- help the immune system fight off infections
-make the person more likely to get other infections of infection-related cancers
-destroys many of these cells that the body can't fight off infections and disease - ANS-Attacks
the body's immune system
AIDS, the last stage of HIV infection - ANS-opportunistic infections or cancers take advantage of
a very weak immune system resulting in
Number Zero - First time patient zero. Gaetan Dugas. HIV enters the US around 1966, Haiti,
then to Africa. Origins ZR59 - Bantu man in 1959. Human Tissue preserved in paraffin wax -
Kunchasa - , 1908 started in humans - Spillover. - ANS-Question 1:Who was the first person
with HIV (Patient 0), as most people understand the story? Who is really believed to be the first
human to have contracted HIV? In what year did he/she live?
When the original virus infects a cell, copies of the virus are made. These copies include error,
this error occurs at a predicable rate; therefore by comparing virus samples, the origins of the
virus can be determined...genetic sequencing has enabled this discovery. - ANS-Question
2:How did researchers determine who the real "Patient 0" was? Scientists revealed where
human HIV originated by looking at genetic diversity between different HIV samples. Explain
how this works.
Africa, they were able to determine the geographic origin of HIV1 from a group of chimps, live in
a corner of Southeastern Cameroon, an area between the Boumba River, Ngoko River, Sangha
River, 100 square miles - most perfect match between the virus that humans have and what
chimps have. - ANS-Question3: Describe where geographically HIV originated and how
researchers hypothesize the virus moved out into the world to become a pandemic.
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