ASCP CG CERTIFICATION EXAM 2024 ACTUAL EXAM
COMPLETE 150 QUESTIONS WITH DETAILED VERIFIED
ANSWERS (100% CORRECT ANSWERS) ALREADY
GRADED A+
What is the correct nomenclature to describe a hematologic
disorder with trisomy 21 in 6 cells and 14 cells that are
normal? - CORRECT ANSWER >>>>47,XY,+21?c[6]/46,XY[14]
?c -- indicates questioning whether the trisomy is
constitutional or not as it was seen in only 6 cells
The G-light bands produced by routine GTG banding
represent: - CORRECT ANSWER >>>>The active regions of
the chromosome
aka euchromatin -- gene-rich and GC rich DNA, early
replicating
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Which of the following is not assocated with a
microdeletion?
Associated with an autosomal dominant mutation in the
CREB or CREBBP gene(s)
Rarely assocated with a deletion in 16p13.3 (12% of cases,
not the predominant cause, detected by FISH)
Presents as facial dysmorphism, broad thumbs, broad big
toes, and growth and mental retardation
The dark bands produced by routune GTG banding
represent: - CORRECT ANSWER >>>>AT-rich regions of the
chromosome
aka heterpchromatin, and gene-poor chromatin, late
replicating DNA
If GTG banded chromosomes appear ghost-like with little
visible banding, one should alter banding prep by: -
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CORRECT ANSWER >>>>Decreasing trypsin time (chewed
out and non-distinct)
If 50 out of 200 interphase nuclei have 3 signals in a
prenatal aneusomy FISH analysis for chromosome 18, the
results are: - CORRECT ANSWER >>>>Consistent with
trisomy 18 or a structural anomaly of chromosome 18
If the same hybridization incubator is used for several
different probe strategies, the stringency for each probe can
be adjusted by: - CORRECT ANSWER >>>>adjusting the
formamide and salt concentrations
Optimal (best) banding quality is achieved for each patient
sample by banding: - CORRECT ANSWER >>>>one trial slide
per patient to ensure BEST quality
In fluorescent microscopy, the exciter and barrier filters
used depend on ___ ? - CORRECT ANSWER >>>>Stain -
because the wavelength for emission can vary per type of
fluorescent stain used (i.e. DAPI)
What is a possible reason a metaphase cannot be located
when switching from the 40x lens to the 100x oil lens? -
CORRECT ANSWER >>>>The 100x objective is slightly
unscrewed (can occur when cleaning the scope)
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What is an action a technologist can take to reduce the risk
of repetitve motion injuries when doing analysis on a
computer? - CORRECT ANSWER >>>>Supporting the arm
that moves the mouse,
Standing and moving around often, and
alternating hands while operating the computer mouse
What is the correct modal number for a patient with Turner
syndrome with an isochromosome Xq? - CORRECT ANSWER
>>>>46 -- because the isochromosome replaces the normal
X, causing Turner syndrome
What should be used on a cultured CVS sample to obtain
more slides for analysis? - CORRECT ANSWER >>>>Trypsin-
EDTA -- to remove adherent cells from the flask or coverslip
to split into more vessels
EDTA improves tryp's effectiveness (chelating agent)
Cyto studies were ordered on a prenatal patient at 12 weeks
gestation after an abnormality was detected via ultrasound.
2 of 15 colonies from seperate primary cultures showed an
abnormal cell line of 47,XX,+21. The next step would be to
___ ? - CORRECT ANSWER >>>>Report the result as this is a
true mosaic case and suggest:
repeating amniocentesis,
repeating a detailed ultrasound, or
request percutaneous umbilical blood sample (PUBS)
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