NAPLEX 2023 QUESTIONS AND CORRECT ANSWERS
LATEST UPLOAD 2024/2025 BEST EXAM SOLUTION
RATED A+ FOR SUCCESS
Key drugs that can cause hypothyroidism - CORRECT ANSWERS "I TALC"
Hyperthyroid in pregnancy - CORRECT ANSWERS Hyperthyroidism during pregnancy should be
treated with propylthiouracil (PTU) during the first trimester then methimazole during the second
and third trimesters. Although methimazole is a teratogen, the teratogenic effects are less during the
second and third trimesters, and PTU can cause liver failure, which is why it is substituted out.
Cushing's syndrome - CORRECT ANSWERS Adrenal gland produces too much cortisol or exogenous
steroids are taken in doses higher than normal amounts of endogenous cortisol
Addison's disease - CORRECT ANSWERS a condition that occurs when the adrenal glands do not
produce enough cortisol; Addisonian crisis (volume depletion and hypotension, which can be fatal)
Steroids: least to most potent - CORRECT ANSWERS (Cute Hot Pharmacists and Physicians Marry
Together & Deliver Babies)
o Cortisone (25 mg): short acting
o Hydrocortisone (20 mg): short acting
o Prednisone (5 mg): intermediate acting
o Prednisolone (5 mg): intermediate acting
o Methylprednisolone (4 mg): intermediate acting
o Triamcinolone (4 mg): intermediate acting
o Dexamethasone (0.75 mg): long acting, highest potency
o Betamethasone (0.6 mg): long acting, highest potency
,NAPLEX 2023 QUESTIONS AND CORRECT ANSWERS
LATEST UPLOAD 2024/2025 BEST EXAM SOLUTION
RATED A+ FOR SUCCESS
Immunosuppression from steroids - CORRECT ANSWERS A patient is immunosuppressed when
using >/= 2mg/kg/day or >/= 20mg/day of prednisone or prednisone equivalent for >2 weeks
Immunosuppressed patients cannot receive live vaccines and have a high risk of infection
steroid will need to be slowly tapered off: reduce 10-20% every few days (tapers can last 7-14 days,
longer or shorter)
Traditional DMARDs (disease modifying anti-rheumatic drugs) - CORRECT ANSWERS MTX (Trexall):
first line in RA
Hydroxychloroquine (Plaquenil)
Sulfasalazine
Leflunomide (Arava)
Traditional DMARDs (disease modifying anti-rheumatic drugs): MTX - CORRECT ANSWERS MTX
(Trexall): first line in RA
- irreversibly binds and inhibit dihydrofolate reductase, inhibiting folate
Used for a variety of diseases including RA (typically add on therapy to MTX)
Needles are provided
Each has a pregnancy registry
Boxed warnings: serious infections, malignancies
Warnings: demyelinating desease, hep B reactivations, HF, hepatotoxicity, lupus-like syndrome,
seizures, myelosuppression
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