ONCC-AOCNP Latest Test Guide (Q & S) - All Subject Areas - 2024.
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Course
ONCC
Institution
ONCC
ONCC-AOCNP Latest Test Guide (Q & S) - AlONCC-AOCNP Latest Test Guide (Q & S) - All Subject Areas - 2024.ONCC-AOCNP Latest Test Guide (Q & S) - All Subject Areas - 2024.ONCC-AOCNP Latest Test Guide (Q & S) - All Subject Areas - 2024.l Subject Areas - 2024.
,1. Which of the following genetic markers is most commonly associated
with hereditary breast and ovarian cancer syndrome?
- A) MLH1
- B) BRCA1
- C) TP53
- D) APC
Correct Answer: B) BRCA1
Rationale: BRCA1 and BRCA2 mutations significantly increase the risk
for breast and ovarian cancers.
2. What is the most effective primary prevention strategy for colorectal
cancer?
- A) Screening colonoscopy
- B) Lifestyle modifications, including diet and exercise
- C) Genetic testing
- D) Aspirin prophylaxis
Correct Answer: B) Lifestyle modifications, including diet and exercise
Rationale: While screening is crucial, primary prevention through
lifestyle changes can significantly reduce risk.
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,#### Diagnosis, Staging, and Treatment Planning
3. In the TNM staging system, what does the 'M' represent?
- A) Metastasis
- B) Mutation
- C) Margin
- D) Location
Correct Answer: A) Metastasis
Rationale: 'M' in TNM stands for the presence or absence of distant
metastasis.
4. Which imaging modality is most sensitive for detecting brain
metastases?
- A) X-ray
- B) CT scan
- C) MRI
- D) PET scan
Correct Answer: C) MRI
Rationale: MRI is the preferred imaging technique for detecting brain
lesions due to its higher sensitivity.
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, #### Cancer Treatment
5. Which of the following chemotherapy regimens is most commonly
used in the treatment of non-small cell lung cancer (NSCLC)?
- A) CHOP
- B) FOLFOX
- C) cisplatin + pemetrexed
- D) R-CHOP
Correct Answer: C) cisplatin + pemetrexed
Rationale: This combination is a standard approach for NSCLC,
particularly in non-squamous histologies.
6. What is the primary mechanism of action for trastuzumab (Herceptin)?
- A) DNA intercalation
- B) Inhibition of topoisomerase
- C) HER2 receptor blockade
- D) Inhibition of angiogenesis
Correct Answer: C) HER2 receptor blockade
Rationale: Trastuzumab specifically targets the HER2 protein,
overexpressed in certain breast cancers.
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