Stannous fluoride (SnF2) gel is used for ? - ✔️✔️Fluoride therapy
When is SnF2 contraindicated for fluoride treatment? What is used instead? - ✔️✔️Taste poorly
tolerated and ceramic restorations
Neutral pH sodium NaF gels (Thera-Flur-N)
Max amount of NaF allowed in container? How much F? - ✔️✔️264 mg of NaF
120 mg of F
Probable toxic dose of F? - ✔️✔️5 mg F/kg
Xerostomia provides a good environment for overgrowth of what bacteria? What 2 meds are
used to treat this? - ✔️✔️C. albicans (secondary/opportunistic infection)
Nystatin (topical) or Fluconazole (systemic)
Why is Ketoconazole not often used? - ✔️✔️Drug-drug interacts & adverse effects
(F: period irregularities; M: man boobs)
? NT is released to work on ? receptors to modulate functions of smooth or cardiac muscles,
glands, cells - ✔️✔️Acetylcholine works on muscarinic receptors
Main target for meds to combat xerostomia? Agonists or antagonist? - ✔️✔️Muscarinic ACH
receptors of parasympathetic
Agonist
Specific receptor for salivary secretion of acinar cells (target of xerostomia drugs) - ✔️✔️M3
Pilocarpine, Bethanechol and Cevimeline are all what type of drug? - ✔️✔️Parasympathomimetics
2 contraindications of Pilocarpine - ✔️✔️Asthma, loss of salivary gland function
When Pilocarpine binds the M3 receptor it activates Phospholipase C to cleave ? into ? and ?
End effect is to raise intracellular ? - ✔️✔️PIP2
3
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