autoimmune process/ loss of pancreatic beta cells (cells responsible for insulin synthesis and
release into the bloodstream, what matters is total carbs not type - ANS-type 1 etiology/primary
defect
reduced early in disease and completely absent later - ANS-Type 1 insulin levels
insulin replacement mandatory, strict diet control, no oral anti-diabetic drugs, prevent long term
damage, educate the patient, maintain weight, statins & colesyelam reduce high levels of LDL,
ACE inhibitor or ARB reduce risk of HTN and neuropathy - ANS-type 1 treatment
levels may be low(indicates deficiency), normal, high(indicates resistance) - ANS-type 2 insulin
levels
normally asymptomatic, s/s result from insulin resistance and impaired insulin secretion,
hyperinsulinemia - ANS-type 2 symptoms
1. reduced binding of insulin to its receptor
2. reduced receptor numbers
3. reduced receptor responsiveness - ANS-insulin resistance (pharmacodynamics)
most occur secondary to disruption of blood flow
micro/macro vascular damage - ANS-long term complications
, biguanide, initial treatment for type 2 diabetes, GI upset, absorbed in small intestine but not
metabolized so excreted in the kidneys, delay type 2 onset for high risk, can use for gestational
diabetes - ANS-Metformin (Glucophage)
General
1. inhibits glucose production in liver
2. reduces slightly glucose absorption in the gut
3. sensitizes insulin receptors in target tissues (fat &skeletal), thereby increasing glucose uptake
Does not stimulate insulin release from pancreas - ANS-metformin MOA
1. kidney failure because increase lactic acid toxicity
2. deficiency of B12 and folic acid
3. liver disease, HF, prone to lactic acid production
4. reduce consumption of OH - ANS-metformin contraindications
alpha-glucosidase inhibitor
type 2 diabetes w/ diet & exercise third line drug, PO, minimal systemic effects, DOES NOT
DEPEND ON PRESENCE OF INSULIN - ANS-Acarbose(precose)
delays absorption of dietary carbs and thereby reduces postprandial rise in blood glucose -
ANS-Acarbose MOA
flatulence, cramps, abd distention, borborygmus(rumbling), diarrhea
risk of anemia due to poor iron absorption
hypoglycemia when combo
void with metformin due to both GI upset
long term/high dose=liver dysfxn. - ANS-Arcabose side effects/contraindications
2nd generation sulfonylureas, onset 15-30 min, less drug-drug interactions, type 2 diabetes with
calorie restriction and exercise, duration 10-24 hours - ANS-Glipizide (Glucotrol)
stimulating release of insulin from pancreatic islets (no type 1 because no insulin production)
Bind & block ATP-sensitive channels in cell membrane, membrane depolarize-permit influx of
CA+=insulin release - ANS-Glipizide MOA
hypoglycemia*--> will make glucose go lower no matter the level, more likely in pt with
liver/kidney dysfxn (hepatic/renal metabolism), possible cardiac death, teratogen=no
pregnancy/breast feeding (make baby hypoglycemic) - ANS-Glipizide side
effects/contraindications
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