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GMS6504 Exam 1 Questions and answers
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GMS6504 Exam 1 Questions and answers
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GMS6504 Exam 1 Questions and answersWhich of the following would best be described as a system
independent parameter determining pharmacological response?
Receptor affinity for the ligand
When taking a natural agonist and converting it to an antagonist
using synthetic chemistry, what are the desired effects on
affinity and efficacy?
Affinity increases, efficacy decreases
In the Langmuir equation, which variable represents the
proportion of receptors that are bound by ligand?
Kd
If a ligand has an intrinsic activity, α, of 0.54, this ligand is best
considered a _____
partial agonist
If you do a cell culture experiment where you exogenously
express a receptor in cells, which variable in the equation R =
f(α •r • Rt) are you most directly controlling?
Rt
With an efficacy-driven agonist, reducing the number of
receptors present will shift the response curve _____.
, right
Applying the two-state theory of receptors to an ion channel,
which state(s) would be active?
Ropen, ARopen
In a two-state system that allows for spontaneously active
receptors, increasing the expression levels of receptor in the
absence of agonist will have what effect on measured response?
Increase
In the extended ternary complex model of receptors, which
state(s) will result in subsequent downstream signaling? Select
all that apply
ARaG, RaG
Addition of an inverse agonist to a system containing a receptor
that does not spontaneously activate will have what effect on the
measured response in the absence of any other ligand?
Have no effect
You use an agonist to treat two systems that are identical other
than the number of receptors present. System A required 1 mM
of the ligand to reach 100% response while system B required
100 mM. Which system has the larger receptor reserve?
System A
The cellular veil _____ the measured response.
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