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GMS 6551:4 Pharmacokinetics Questions With Complete Solutions
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GMS 6551:4 Pharmacokinetics
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GMS 6551:4 Pharmacokinetics Questions With CompleteSolutions
Through which route is warfarin usually administered?
Oral
Sublingual
Intravenous
Inhalation
Topical Correct Answers Oral
... ...
Through which routes of administration will at least some first-
pass metabolism occur? Select all that apply.
Oral
Sublingual
Rectal
Intravenous
Subcutaneous
Intramuscular
Topical
Transdermal
Inhalation Correct Answers Oral
... ...
Rectal
Would you expect aspirin to be absorbed better at high or low
pH? Hint: Think of the chemical name for aspirin.
High pH
Low pH Correct Answers Low pH
... ...
, Would you expect a more polar or nonpolar drug to have more
bioavailability?
Polar
Nonpolar Correct Answers Nonpolar
... ...
Assuming the same lipophilicity and that all are neutrally
charged (in reality these are horrible assumptions), which drug
would you expect to have the best membrane permeability?
Tylenol
Ibuprofen
Aspirin
Aleve
Codeine Correct Answers Tylenol
... ...
Which family of enzymes catalyzes the majority of phase I drug
metabolism?
GSTs
SULTs
UGTs
NATs
CYPs Correct Answers CYPs
. .. ...
Codeine undergoes which type of phase I metabolism reaction?
Oxidation
Epoxidation
Dealkylation
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