GMS 6540 ( Med Pharm IV): PROBLEM SET 1, GMS 6540
(Med Pharm IV): PROBLEM SET 2, GMS 6540 (Med
Pharm IV): PROBLEM SET 3, GMS 6540 (Med Pharm IV):
PROBLEM SET 4, GMS 6540 (Med Pharm IV):
PROBLEM SET 5, GMS 6540 (Med Pharm IV):
PROBLEM SET 6, GMS 6540...
Genetic changes are required for which of the following to
occur? Select all that apply.
Initiation/Transformation of a cell
Formation of a pre-neoplastic lesion from an initiated cell
Formation of a malignant tumor from a pre-neoplastic lesion
Formation of clinical cancer from a malignant tumor
Metastasis of a clinical cancer Correct Answers
......
Initiation/Transformation of a cell
......
Formation of a malignant tumor from a pre-neoplastic lesion
Formation of clinical cancer from a malignant tumor
Metastasis of a clinical cancer
What effect would a G12V mutation in Ras have on ERK?
It would lead to increased activation of ERK.
It would lead to decreased activation of ERK.
It would increase the stability of ERK.
It would decrease the stability of ERK. Correct Answers It would
...... ......
lead to increased activation of ERK.
,Are cancers more likely to develop mutation that activate or
inactivate Rb?
Activate
Inactivate Correct Answers Inactivate
...... ......
Metabolites of nicotine commonly result in DNA point
mutations. Which type of DNA instability is this an example of?
Genetic instability
Chromosomal instability Correct Answers Genetic instability
...... .... ..
If a human cell underwent endoreduplication followed by failed
cytokinesis, how many chromosomes would you expect that cell
to now contain?
23
46
92
184
368 Correct Answers 184
...... ......
Which of the following statements is true regarding apoptosis.
It does not occur in our bodies under normal circumstances.
Is it a process to ensure cancer cell survival.
Cancer cells must avoid it.
Tumors seek to upregulate it.
It can only be triggered by factors outside the cell. Correct ......
Answers Cancer cells must avoid it.
.... ..
,Which statement best describes the Warburg effect?
The switching of cancer cells from oxidative phosphorylation to
aerobic glycolysis
The switching of cancer cells from aerobic glycolysis to
oxidative phosphorylation
The process of making glycolysis more efficient
The process of making glycolysis less efficient Correct Answers ......
The switching of cancer cells from oxidative phosphorylation to
......
aerobic glycolysis
A patient undergoes an FdG-PET scan. Will a tumor contain
more or less 18fluorodeoxyglucose than normal the surrounding
tissue?
More
Less Correct Answers More
...... ......
Angiogenesis is __________________.
the process of creating blood vessels where none currently
existed
the process of creating new blood vessels from current blood
vessels Correct Answers the process of creating new blood
...... .... ..
vessels from current blood vessels
Is inflammation harmful or beneficial to cancer?
Harmful
Beneficial Correct Answers Beneficial
...... ......
, If a cell expresses a mutant form of EGFR, would this be
considered a tumor specific antigen or a tumor associated
antigen?
Tumor specific antigen
Tumor associated antigen Correct Answers Tumor specific
...... ......
antigen
Which statement best describes how cancer cells overcome the
Hayflick limit?
They upregulated p53
They downregulate p53
They upregulate telomerase
They downregulate telomerase Correct Answers They upregulate
...... ......
telomerase
What chemical causes the most cigarette-related DNA
mutations?
Benzo[a]pyrene
5-Methylchrysene
Chrysene
Benz[a]anthracene
Benzo[e]pyrene Correct Answers Benzo[a]pyrene
...... ... ...
The Epstein-Barr virus, most famous for causing
mononucleosis, also plays a prevalent role in the formation of
what type of cancer?
Non-small cell lung cancer
(Med Pharm IV): PROBLEM SET 2, GMS 6540 (Med
Pharm IV): PROBLEM SET 3, GMS 6540 (Med Pharm IV):
PROBLEM SET 4, GMS 6540 (Med Pharm IV):
PROBLEM SET 5, GMS 6540 (Med Pharm IV):
PROBLEM SET 6, GMS 6540...
Genetic changes are required for which of the following to
occur? Select all that apply.
Initiation/Transformation of a cell
Formation of a pre-neoplastic lesion from an initiated cell
Formation of a malignant tumor from a pre-neoplastic lesion
Formation of clinical cancer from a malignant tumor
Metastasis of a clinical cancer Correct Answers
......
Initiation/Transformation of a cell
......
Formation of a malignant tumor from a pre-neoplastic lesion
Formation of clinical cancer from a malignant tumor
Metastasis of a clinical cancer
What effect would a G12V mutation in Ras have on ERK?
It would lead to increased activation of ERK.
It would lead to decreased activation of ERK.
It would increase the stability of ERK.
It would decrease the stability of ERK. Correct Answers It would
...... ......
lead to increased activation of ERK.
,Are cancers more likely to develop mutation that activate or
inactivate Rb?
Activate
Inactivate Correct Answers Inactivate
...... ......
Metabolites of nicotine commonly result in DNA point
mutations. Which type of DNA instability is this an example of?
Genetic instability
Chromosomal instability Correct Answers Genetic instability
...... .... ..
If a human cell underwent endoreduplication followed by failed
cytokinesis, how many chromosomes would you expect that cell
to now contain?
23
46
92
184
368 Correct Answers 184
...... ......
Which of the following statements is true regarding apoptosis.
It does not occur in our bodies under normal circumstances.
Is it a process to ensure cancer cell survival.
Cancer cells must avoid it.
Tumors seek to upregulate it.
It can only be triggered by factors outside the cell. Correct ......
Answers Cancer cells must avoid it.
.... ..
,Which statement best describes the Warburg effect?
The switching of cancer cells from oxidative phosphorylation to
aerobic glycolysis
The switching of cancer cells from aerobic glycolysis to
oxidative phosphorylation
The process of making glycolysis more efficient
The process of making glycolysis less efficient Correct Answers ......
The switching of cancer cells from oxidative phosphorylation to
......
aerobic glycolysis
A patient undergoes an FdG-PET scan. Will a tumor contain
more or less 18fluorodeoxyglucose than normal the surrounding
tissue?
More
Less Correct Answers More
...... ......
Angiogenesis is __________________.
the process of creating blood vessels where none currently
existed
the process of creating new blood vessels from current blood
vessels Correct Answers the process of creating new blood
...... .... ..
vessels from current blood vessels
Is inflammation harmful or beneficial to cancer?
Harmful
Beneficial Correct Answers Beneficial
...... ......
, If a cell expresses a mutant form of EGFR, would this be
considered a tumor specific antigen or a tumor associated
antigen?
Tumor specific antigen
Tumor associated antigen Correct Answers Tumor specific
...... ......
antigen
Which statement best describes how cancer cells overcome the
Hayflick limit?
They upregulated p53
They downregulate p53
They upregulate telomerase
They downregulate telomerase Correct Answers They upregulate
...... ......
telomerase
What chemical causes the most cigarette-related DNA
mutations?
Benzo[a]pyrene
5-Methylchrysene
Chrysene
Benz[a]anthracene
Benzo[e]pyrene Correct Answers Benzo[a]pyrene
...... ... ...
The Epstein-Barr virus, most famous for causing
mononucleosis, also plays a prevalent role in the formation of
what type of cancer?
Non-small cell lung cancer
