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Myasthenia Gravis: Questions And Answers (Verified)
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Myasthenia Gravis: Questions And Answers (Verified)
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Myasthenia Gravis: Questions And Answers (Verified)Myasthenia Gravis Right Ans - autoimmune disorder that results in mm
weakness and rapid mm fatigue due to antibodies
antibodies Right Ans - 1.block or destroy acetylcholine receptors
2.block function of MuSK
3.block function of LRP4 (lipoprotein related protein)
what gland is thought responsible to trigger abnormal production of these
antibodies? Right Ans - thymus
what characteristics is common in this disease that is also seen in RA/MS?
Right Ans - periods of remission and exacerbations
etiology Right Ans - acquired immunological abnormality (genetic
abnormality in some pts)
etiology is assoc with Right Ans - 1.other autoimmune diseases
(RA/DM/SLE/hyperthyroidism/Hashimotos)
2.hyperplasic of thymus (precancerous cells)
3.thymona:benign thymus gland tumor
Hashimotos disease Right Ans - thyroid condition that involves others
symptoms such as severe vascular constriction)
thymus gland is responsible for what? Right Ans - production of t cells in
the immune system
treatment of choice for young patients? Right Ans - thymectomy (benefits
are often not realized for many years)
affects which gender more? Right Ans - female
age of onset Right Ans - M:older than 60
F:20-40
, general symptoms Right Ans - waxing/waning mm fatigue and weakness
that worsens with exercise and improves with rest
initial symptoms Right Ans - 1.ocular:weakness in eye mm and eyelid
(ptosis and diploplia)
2.oropharyngeal mm weakness (swallowing, talking chewing, facial
expressions)
3.neck and limb weakness
types Right Ans - ocular
generalized
Myasthenia CRISIS
ouclar type is characterized by? Right Ans - weakness in eye mm and eyelid
generalized is characterized by? Right Ans - 1.starts as ocular and
progresses to other mm
2.progress to mm groups within 1-2 years of onset
UE>LE
3.can involve oropharyngeal mm weakenss
Myasthenia CRISIS is characterized by? Right Ans - affects respiratory mm
often assoc with severe infections
symptoms with Generalized Myasthenia Gravis Right Ans - 1.initial
weakness in several mm groups
2.severity of weakness fluctuates during day (least to worst) due to decreased
achecto
3.severity progresses over time, peaking within a few years of onset
4.periods of relapse/remission
factors that exacerbate symptoms Right Ans - stress/fatigue
systemic illness
hyper/hypothyroidism
pregnancy
increase in body temp
meds (antis, narcotics, b blockers, anesthetics)
diagnosis often takes Right Ans - months and differential diagnosis is used
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