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Pharm 895 Anticonvulsants Practice Questions with Correct Answers
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Pharm 895 Anticonvulsants Practice Questions with Correct Answers
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©PREP4EXAMS @2024 [REAL EXAM DUMPS] Wednesday, July 17, 2024 1:27 AMPharm 895 Anticonvulsants Practice
Questions with Correct Answers
Epilepsy - ✔️✔️Recurrent, unprovoked seizures
Seizure types - ✔️✔️Partial, which includes simple, complex, or partial that secondarily
becomes generalized
AND
Generalized, which includes tonic-clonic, absence, tonic, atonic, and clonic/myoclonic
Dilantin (Phenytoin) - ✔️✔️Indicated for partial seizures and generalized tonic-clonic seizures
MOA: Prolong inactivated state of Na channel, inhibit glutamate release, enhance GABA
release
Takes 5-7 days to get to steady state
90% protein bound
may induce myoclonic seizures
be cautious about increasing daily dose- levels accumulate and stack
Diethylene glycol diluent can cause rate-related hypotension
Cannot be given IM
Limb threatening phlebitis called purple glove syndrome
1
, ©PREP4EXAMS @2024 [REAL EXAM DUMPS] Wednesday, July 17, 2024 1:27 AM
Dose related effects: Nystagmus, diplopsia, ataxia, sedation
Non-dose related: gingival hyperplasia, hirsuitism, rash, fever, hepatotoxicity (dose adjust in
hepatic failure)
Long term: coarse facial features, mild peripheral neuropathy, abnormal vit D metabolism
(supplement with folic acid, Ca and vit D)
Cerebyx (Fosphenytoin) - ✔️✔️Indicated for partial seizures and generalized tonic-clonic
seizures
Prodrug of phenytoin
Can be administered IM
Dose related effects: Nystagmus, diplopsia, ataxia, sedation
Non-dose related: gingival hyperplasia, hirsuitism, rash, fever, hepatotoxicity (dose adjust in
hepatic failure)
Long term: coarse facial features, mild peripheral neuropathy, abnormal vit D metabolism
(supplement with folic acid, Ca and vit D)
Tegretol, Carbatrol (Carbamazepine) - ✔️✔️Indicated for partial seizures and generalized
tonic-clonic seizures
MOA: Prolong inactivated state of Na channels
Induces it's own metabolism, has many drug interactions
may induce myoclonic seizures
dose reduce in hepatic failure
2
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