Mock CG(ASCP) Certification exam 1 - Part 1
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A case with suspected microdeletion has arrived at the laboratory. What measures will
be taken in order to rule out this abnormality?
a. Increased concentration of growth serum
b. Increased concentration of mitotic arresting agent
c. High resolution banding
d. Increased concentration of L-glutamine - CORRECT ANSWER: High resolution
banding
A cell with three copies of each chromosome is classified as:
a. Mosaic
b. Haploid
c. Trisomic
d. Triploid - CORRECT ANSWER: Triploid
A couple is referred to a clinical cytogenetics laboratory due to a prior history of multiple
spontaneous abortions. A peripheral blood specimen is obtained for constitutional
chromosome analysis, and it is discovered that the male is a carrier of a Robertsonian
translocation [der(13;14)(q10;q10)] while the female is chromosomally normal. What is
the likelihood that the next conception will be a miscarriage? (Assume that all viable
zygotes, even in phenotypical abnormal, will come to term.)
a. 33%
b. 25%
c. 100%
d. 50% - CORRECT ANSWER: 50%
,A cytogenetic technologist suspects an inversion of chromosome 9 with G-banding
analysis. Which banding technique would help confirm this observation?
a. A-banding
b. C-banding
c. Q-banding
d. All of the above - CORRECT ANSWER: C-banding
A diagnosis of true mosaicism can only be made when:
a. The abnormal cell lines are found in the same culture vessel
b. The same abnormal cell line is found in at least two independent culture vessels
c. Two or more abnormal cell lines are found the same in situ culture
d. When 46,XX and 46,XY cell lines are found in the same culture vessel - CORRECT
ANSWER: The same abnormal cell line is found in at least two independent culture
vessels
A digital image is made up of:
a. Lines
b. Pixels
c. Arcs
d. Tangents - CORRECT ANSWER: Pixels
A male requests a chromosome karyotype to be made on his peripheral blood
lymphocytes due to a history of infertility. The cytogenetics laboratory reports a diploid
46,XY karyotype with an unusually large Y chromosome which fluoresces brightly when
stained with Q-banding. Which of the following information should be given to this
individual regarding his karyotype and his infertility?
a. The increased length of the heterochromatic region on the Y chromosome is likely the
reason for this individuals infertility
b. The increased length of the heterochromatic region on the Y chromosome has been
shown to increase the likelihood of nondisjunction events occurring in meiosis
c. The length of the heterochromatic region on the Y chromosome has no clinical
significance and is highly unlikely the reason for this individuals infertility
, d. Both a and b - CORRECT ANSWER: The length of the heterochromatic region on the
Y chromosome has no clinical significance and is highly unlikely the reason for this
individuals infertility
A pathologist is sending solid tumor specimens to a cytogenetic laboratory for analysis.
What instructions should be given to the pathologist concerning the preparation and
transport of the specimen to insure the highest chance of successful culture?
a. Ensure the sterility of the specimen by placing it in formalin until it reaches the
laboratory.
b. Ensure that the specimen does not contain necrotic or fatty tissue.
c. Ensure that the specimen is transported on dry ice to prevent decomposition.
d. All of the above. - CORRECT ANSWER: Ensure the specimen does not contain
necrotic or fatty acid
A quality control program in a clinical cytogenetics laboratory includes:
A. The testing of tissue culture media
B. The routine monitoring and standardization of equipment
C. The testing of various reagents
D. All of the above - CORRECT ANSWER: All of the above
A rare, severely debilitating virus must be handled in which of the following biosafety
cabinets?
A. Class III
B. Class II
C. Class I
D. Laminar flow hood - CORRECT ANSWER: Class III
A solid tumor specimen can NOT be shipped from the hospital to a
cytogenetics laboratory in another city due to a major holiday which will not allow the
sample to be shipped via Federal Express Overnight delivery. How should the sample
be stored so that the cells will remain alive until they can be delivered and placed in
culture?
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