Brooker Genetics 5E: Chapter 17
homologous recombination - ANS the exchange of DNA segments between homologous
chromosomes.
site-specific recombination - ANS when two different DNA segments break and rejoin with each
other at a specific site. this occurs during the integration of certain viruses into the host
chromosome and during the rearrangement of immunoglobulin genes.
transposition - ANS the phenomenon of transposon movement.
SCE (sister chromatid exchange) - ANS the phenomenon in which crossing over occurs
between sister chromatids, thereby exchanging identical genetic material.
genetic recombination - ANS (1) the process in which chromosomes are broken and then
rejoined to form a novel genetic combination. (2) the process in which alleles are assorted and
passed to offspring in combinations that are different from the parents.
BrdU (5-bromodeoxyuridine) - ANS a base analog that can be incorporated into chromosomes
during DNA replication. The presence of this analog can affect the ability of the chromosomes to
absorb certain dyes. This is the basis for the staining of harlequin chromosomes.
gene conversion - ANS the phenomenon in which one allele is converted to another due to
genetic recombination and DNA repair.
Holliday model - ANS a model to explain the molecular mechanism of homologous
recombination.(describes the molecular steps that occur during homologous recombination btw
homologous chromosomes.)
Holliday junction - ANS a site where an unresolved crossover has occurred between two
homologous chromosomes.
branch migration - ANS the lateral movement of Holliday junction.
heteroduplex - ANS a double-stranded region of DNA that contains one
resolution - ANS the last stage of homologous recombination, in which the entangled DNA
strands become resolved into two separate structures.
double-strand break model - ANS a model for homologous recombination in which the event
that initiates recombination is a double-strand break in one of the double helices.
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