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Pharmacology: Sedative-Hypnotic Drugs Detailed Questions And Expert Answers
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Pharmacology: Sedative-Hypnotic Drugs Detailed Questions And Expert Answers
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Pharmacology: Sedative-Hypnotic Drugs DetailedQuestions And Expert Answers
A sedative has a calming effect and is known as an - ANS Anxiolytic
A hypnotic does what - ANS Puts you to sleep
What are 6 reasons benzodiazepines are used? - ANS 1) Anxiolytic: GAD, PD, OCD
2) Hypnotic: Insomnia
3) Muscle Relaxant: Spasticity
4) Anticonvulsant: Status epileptics
5) Pre-operative use
6) Alcohol withdraw
Are benzodiazepines general anesthetics? - ANS No THEY ARE NOT!
Are benzodiazepines analgesics? - ANS NO THEY ARE NOT!
What is the first and second effects that benzodiazepines cause as you increase
dose - ANS Sedation then sleep at higher doses
, The GABA type A receptor does what - ANS When GABA binds > opens the Cl- ion
channel > Increases Cl- influx > hyperpolarization and therefore inhibits neuronal
firing
What 2 classes of drugs increase GABA effect - ANS 1) Benzodiazepine
2) Barbiturate
What do BZ's do? - ANS Bind to a site on the GABA type A receptor and increase
the frequency that the Cl- channel opens in the presence of GABA
Describe the pathophysiology of anxiety disorders in general? - ANS There is an
increase in neuronal firing mainly due to reduction or abnormal functioning of
GABA type A receptors
BZs bind to GABA type A receptors located where - ANS Limbic system (emotions)
What do BZ's do in the limbic system - ANS Enhance the inhibition of neurons and
therefore produce anxiolytic effect
Ultra short BZ's are used for - ANS Pre-operative procedures
Short and intermediate BZ's are used mainly for - ANS Insomnia
Long acting BZ's are used for - ANS Anxiety
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