WEST VIRGINIA UNIVERSIRTY- (WV) : 26506
-increase: aka polycythemia; raises blood viscosity making it difficult to flow, high blood
pressure, increased risk of stroke; caused by tissue hypoxia, blood doping, use of EPO
by athletes, and abnormal increases in RBC production
-decrease: menstruation in women; anemia
define reticulocyte count and provide examples of conditions that increase and
decrease it - ✔️✔️-measures the rate of erythropoiesis
-increase: indicates good red bone marrow response to previous blood loss or to iron
therapy; could point to illegal use of epoetin alfa by an athlete
-decrease: indicates a shortage of erythropoietin or an inability of the red bone marrow
to respond to EPO in anemia (nutritional deficiency or leukaemia)
describe what happens to RBCs when they are damaged or die, including the fate of
hemoglobin breakdown - ✔️✔️1) macrophages in the spleen, liver, or red bone marrow
phagocytize ruptured or worn-out RBCs
2) the heme and globin parts of Hgb are split apart
3) globin is broken down into amino acids which can be reused to synthesize other
proteins
4
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