Exam (elaborations)
UNE BIOCHEMISTRY UNIT 2 TEST
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UNE BIOCHEMISTRY UNIT 2 TEST
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UNE BIOCHEMISTRY UNIT 2 TEST3, 2, 4, 1 - Answers -Order the following statements to illustrate the correct cascade of
events that occurs after ligand binding of G-protein coupled receptor (heptahelical
receptor).
1. Degradation of cAMP by phosphodiesterase
2. Dissociation of Gβ and Gγ subunits
3. G protein exchanges GDP for GTP in the G-αs subunit
4. Activation of adenylyl cyclase (effector E) to generate cAMP
Nuclear localization signal - Answers -A suspected mutation in the cortisol receptor is
discovered. Cortisol can still bind its receptor but the dimerized complex remains in the
cytosol. Based on this description which region on the receptor is likely impacted?
Free fatty acids - Answers -What is the primary oxidized fuel for skeletal muscle in the
fasted state?
Glucagon - Answers -Caffeine is a natural inhibitor of phosphodiesterase. If you were to
consume a large amount of coffee you would likely see a prolonged response to which
of the following stimulants or hormones?
Protein Kinase B - Answers -In the event that PI-3 kinase is not activated downstream
of insulin, which of the following proteins would not be able to dock to the membrane?
Intolerance to dietary fructose - Answers -A 9-month-old girl is suffering from vomiting,
lethargy, and poor feeding behavior. Her mother reports that the symptoms began
shortly after the baby was given some cereal and mashed bananas by her
grandparents. The baby's symptoms seemed to resolve after breastfeeding was
resumed. Which of the following is the most likely diagnosis?
Both glycogen phosphorylase and glycogen synthase are phosphorylated - Answers -
Glycogenolysis and glycogen synthesis are regulated in such a way that neither process
is active at the same time. During the fasted state, (ratio of insulin to glucagon is low)
which of the following best characterizes the regulation of these pathways?
Dephosphorylated and released into the blood to maintain blood glucose. - Answers -
When the insulin to glucagon ratio is low, glycogenolysis is activated in the liver. Which
of the following is the primary fate of the glucose 6-phosphate released under these
conditions?
Pyruvate carboxylase deficiency - Answers -A 1-month-old boy is brought to the
emergency department in a coma after sleeping through the night and failing to awaken
in the morning. He is given intravenous glucose and awakens. Serum levels of
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