Clozapine REMS Certification Exam
Questions with Correct Verified
Solutions 100% Guaranteed Pass
1. A patient taking clozapine with BEN presents with an ANC of
400, what do you do? - ANS ✔- Hematology consult
- Interrupt treatment
- ANC monitoring daily until 750, then 3x/week until ANC is greater than
patient's baseline
2. T/F: Clozapine is a substrate of P450 isozymes. - ANS ✔True
3. Which CYP1A2 inhibitor medications should a provider be
aware of when prescribing clozapine? What should the provider
do if someone is taking one of these medications? - ANS
✔Fluvoxamine
Ciprofloxacin
Enoxacin
--> Reduce clozapine by 1/3 dose
4. T/F: Patients with BEN are not at increased risk for developing
clozapine-induced neutropenia. - ANS ✔True
Clozapine REMS Certification
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Clozapine
5. T/F: If ANC is less than 1500, a repeat ANC measurement within
24 hours should be completed. - ANS ✔True
6. A patient on clozapine presents with a fever of 100˚F. What does
the NP do? - ANS ✔Monitor closely. If fever is equal to or greater
than 101.3 --> Interrupt clozapine treatment & Obtain ANC
7. T/F: Weaning off clozapine is indicated when discontinuing
clozapine for moderate to severe neutropenia. - ANS ✔False
Abrupt treatment discontinuation is necessary for moderate to severe
neutropenia that you suspect is caused by clozapine
8. When discontinuing clozapine, what is the necessary reporting
step? - ANS ✔Submit decision to Clozapine REMS by either signing
into the website, calling their contact center, or faxing patient status
form.
9. You recently discontinued your patient's clozapine prescription
and they're now presenting with a fever of 102˚F. What is the
NP's next steps? - ANS ✔Monitor ANC during the 2 weeks after
discontinuation
Any fever over 101.3˚F ^
10. NPs should be mindful of __________ symptoms and ________
_______ when their patients have recently discontinued clozapine.
- ANS ✔Psychotic symptoms
Cholinergic rebound
Clozapine REMS Certification
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