GESLAAGD IN EERSTE ZIT!!! Biochemie I wordt gegeven in 2e bachelor Diergeneeskunde, UGent door prof. Meyer.
Deze samenvatting bevat zowel algemene info, de strategie en de 2 delen ( de 5 complexen) van het proces oxidatieve fosforylatie. Er moet niet zelf getekend worden.
Bestaat ook in bundel (ko...
H5: OXIDATIEVE FOSFORYLATIE
• In de binnenste membraan ipv matrix (krebs)
• Laatste deel oxidatieve verbranding => doel ATP uit NADH en (FADH2)/QH2
• 5 integrale membraan proteïnen of enzymcomplexen (I-V)
• Opbouw H+ gradiënt gekoppeld aan e- transport naar O2
• Principe: ATP synthese in 2 delen:
o opstapeling chemische energie via opbouw H+ gradiënt
▪ (door gereduceerde co-enzymes lang 1 kant van de membraan, thermodynamica)
o vrijstelling chemische energie via terugstroom H+
I III IV V
II = plan B
STRATEGIE E- TRANSPORTKETEN
• Recyclage: ademhalingsketen kan continu werken
• 2 mobiele coënzymen: Q & cytochroom c, geven 2e- door van I of II naar III, resp. van III naar IV
• Complex II = succinaat dehydrogenase complex Krebs, levert als enige géén energie voor opbouw H+ gradiënt
• Kritische substraten: NADH, O2 en ADP
• 3 oxido-reductasen, 1 oxidase:
o I = NADH - ubiquinone oxidoreductase
o II = succinaat - ubiquinone oxidoreductase
o III = ubiquinol - cytochroomc oxidoreductase
o IV = cytochroom c oxidase
• Welke coënzymen zijn belangrijk in
het e- transport ?
o NAD+ + H- => NADH
o FAD + 2e- + 2H+ => FADH2
o Q + 2e-+ 2H+ => QH2
o Cyt a, b of c met Fe 3+ => Fe 2+
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller tineh. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $3.20. You're not tied to anything after your purchase.
