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  3. Universiteit Gent (UGent)
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  5. Bachelor In De Diergeneeskunde
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  7. Biochemie 1

Summary

Samenvatting H4 krebscyclus

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  • Course
  • Biochemie 1
  • Institution
  • Universiteit Gent (UGent)

GESLAAGD IN EERSTE ZIT!!! Biochemie I wordt gegeven in 2e bachelor Diergeneeskunde, UGent door prof. Meyer. Deze samenvatting bevat zowel de voorbereiding, het mechanisme (deel 1 en 2) als de controle en regeling van de krebs. Bij de voorbereiding moet er niets zelf aangevuld worden. Bij het mechan...

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Document information

  • October 24, 2019
  • 4
  • 2019/2020
  • Summary

Subjects

  • biochemie
  • meyer
  • chemie
  • krebscyclus
  • citroenzuurcyclus
  • g000719a
  • samenvatting

Written for

  • Universiteit Gent (UGent)
  • Bachelor in de Diergeneeskunde
  • Biochemie 1
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1  review

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By: inesmievis • 3 year ago

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Content preview

H4: KREBS CYCLUS
VOORBEREIDING KREBS

• = pyruvaat => acetyl-CoA + CO2 via oxidatieve decarboxylatie
• Via 5 coënzymen: TPP → lipoamide → HS-CoA → FAD → NAD+

1. OXIDATIEVE DECARBOXYLATIE VIA E1
• Coënzyme TPP
• acetyl + 2 e•-transfer via OH*-ethyl-TPP,
afsplitsingCO2
• H+ tijdelijk gebonden

2. REDOX REACTIE VIA E1
• doel= recyclage TPP van E1 door oxidatie
• reductie via H- van coënzyme lipoamide van E2
• acetyl-transfer via acetyl-dihydrolipoamide


3. TRANSFER REACTIE VIA E2
• acetyl-groep van dihydrolipoamide naar HS-CoA




4. REDOX REACTIE VIA E3
• doel= recyclage lipoamide
• FAD + dihydro-lipoamide => lipoamide+ FADH2



5. REDOX REACTIE VIA E3
• doel= recyclage FAD
• NAD+ + FADH2 => FAD + NADH (+ H+)

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