GESLAAGD IN EERSTE ZIT!!! Biochemie I wordt gegeven in 2e bachelor Diergeneeskunde, UGent door prof. Meyer.
Deze samenvatting bevat zowel een algemene kijk, het katabolisme ( met de voorbereiding, de opbouw en energie, het mechaniscme, het kwantitatief effect en wat slotopmerkingen) als het anabol...
• Kata: acetyl eraf (nr krebs) => winst
• Kleine investering CO-A, groot rendement
1. KATABOLISME
• Wat: oxidatieve afbraak C-skelet
• In mitochondriën, voorbereiding in cytosol
VOORBEREIDING
I. ACTIVATIE VETZUUR: in cytosol, via synthase, ATP verbruik, HS-CO-A => acyl CO-A
II. UNIEK TRANSPORTMOLECULE acyl CO-A naar de mitochondria
• CARNTINE-SHUTTLE helpt geladen acyl CO-A door binnenste membraan
1) carnitine acyl transferase I
• Intermembr.: doorgeefarm
• Acylgroep van HS-CoA nr carnitine
2) translocase!
• Nr binnenste membraan
• Acylgroep komt los v carnitine
3) carnitine acyl transferase II
• Omgek. Stap 1 in mitoch. Matrix
• Acylgroep van carnitine naar nieuw
melecule HS-CoA
• => nieuwe acyl coA
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