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Samenvatting H6 bèta oxidatie $3.20
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Samenvatting H6 bèta oxidatie

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GESLAAGD IN EERSTE ZIT!!! Biochemie I wordt gegeven in 2e bachelor Diergeneeskunde, UGent door prof. Meyer. Deze samenvatting bevat zowel een algemene kijk, het katabolisme ( met de voorbereiding, de opbouw en energie, het mechaniscme, het kwantitatief effect en wat slotopmerkingen) als het anabol...

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  • October 25, 2019
  • January 27, 2020
  • 4
  • 2019/2020
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H6:  - OXIDATIE
ALGEMEEN

• Kata: acetyl eraf (nr krebs) => winst
• Kleine investering CO-A, groot rendement

1. KATABOLISME

• Wat: oxidatieve afbraak C-skelet
• In mitochondriën, voorbereiding in cytosol

VOORBEREIDING

I. ACTIVATIE VETZUUR: in cytosol, via synthase, ATP verbruik, HS-CO-A => acyl CO-A




II. UNIEK TRANSPORTMOLECULE acyl CO-A naar de mitochondria
• CARNTINE-SHUTTLE helpt geladen acyl CO-A door binnenste membraan

1) carnitine acyl transferase I

• Intermembr.: doorgeefarm
• Acylgroep van HS-CoA nr carnitine




2) translocase!

• Nr binnenste membraan
• Acylgroep komt los v carnitine




3) carnitine acyl transferase II

• Omgek. Stap 1 in mitoch. Matrix
• Acylgroep van carnitine naar nieuw
melecule HS-CoA

• => nieuwe acyl coA

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