NIH Principals of Clinical Pharmacology Practice Questions and Answers (100% Pass
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Course
NIH IPPCR
Institution
NIH IPPCR
NIH Principals of Clinical Pharmacology
Practice Questions and Answers (100% Pass)
Some clinical situations require administration of an IV loading (initial) dose of a drug to
establish a therapeutic plasma concentration without delay. Which of the following is a
determinant of the initial pla...
NIH Principals of Clinical Pharmacology 2024-2025
Practice Questions and Answers (100% Pass)
Some clinical situations require administration of an IV loading (initial) dose of a drug to
establish a therapeutic plasma concentration without delay. Which of the following is a
determinant of the initial plasma concentration of a drug given by rapid IV infusion (i.e.
bolus dose)? - ✔️✔️The central compartment volume of distribution
The first-order distribution rate constant
The elimination clearance rate
The intercompartmental clearance rate
Which of the following elements is NOT required by federal regulations to be included in
every informed consent form? - ✔️✔️Confidentiality of records
Compensation for injuries
Requirement for advanced directives
Voluntariness and right to withdraw
Therapeutic Drug Monitoring should be considered for a drug with which of the following
characteristics? - ✔️✔️Narrow therapeutic index with variable interpatient
pharmacokinetics
Generally well tolerated over a wide therapeutic range
Well-established physiologic biomarker to guide dosing
Therapeutic Drug Monitoring should be considered for all drugs regardless of
pharmacokinetic properties
What is the clinical relevance of P-glycoprotein (P-gp)? - ✔️✔️P-gp is an SLC transporter
implicated in major drug-drug interactions
P-gp is an ABC transporter implicated in major drug-drug interactions
P-gp is a hepatic CYP enzyme implicated in major drug-drug interactions
P-gp is an intestinal CYP enzyme implicated in major drug-drug interactions
Drug G is administered in an active form and converted to an inactive metabolite by
CYP2D6. If Drug G is administered to a patient who is a poor metabolizer, what is the
likely outcome? - ✔️✔️The efficacy will be reduced
The metabolism will be increased
The toxicity will be increased
The metabolism will be as expected
A patient is receiving an aminoglycoside antibiotic for the treatment of a serious
infection. PK samples today revealed a peak within acceptable limits but a trough much
lower than the target concentration. What is the best approach to increase the trough
concentration? - ✔️✔️Reduce the dosing interval (i.e. shorten the time between doses)
Extend the dosing interval (i.e. lengthen the time between doses)
Increase the dose
Decrease the dose
Which of the following is TRUE regarding pharmacokinetic changes in the elderly? -
✔️✔️Drug distribution of hydrophilic drugs increases with age
Phase II reactions change little with age
Renal elimination increases with age
Gastrointestinal absorption increases with age
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