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N405 - Pathopharmacology III Study Guide Exam Questions Fully Answered.

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Which of the following cellular changes occur with shock? SATA. A) Cells are deprived of oxygen and nutrients, so they produce energy via aerobic metabolism B) Cells are deprived of oxygen and nutrients, so they produce energy via anaerobic metabolism C) Cells swell and cell membrane becomes per...

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  • August 16, 2024
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COCOSOLUTIONS
N405 - Pathopharmacology III Study
Guide Exam Questions Fully Answered.
Which of the following cellular changes occur with shock? SATA.

A) Cells are deprived of oxygen and nutrients, so they produce energy via aerobic metabolism

B) Cells are deprived of oxygen and nutrients, so they produce energy via anaerobic metabolism

C) Cells swell and cell membrane becomes permeable, leading to F&E shifts

D) Glycogen stores are depleted due to continued activation of stress response

E) Hypoglycemia and insulin intolerance occur - Answer B) Cells are deprived of oxygen and nutrients,
so they produce energy via anaerobic metabolism

C) Cells swell and cell membrane becomes permeable, leading to F&E shifts

D) Glycogen stores are depleted due to continued activation of stress response



It's not E because hyperglycemia and insulin resistance occur



Which of the following are released in stress states? SATA.

A) Catecholamines

B) Inflammatory cytokines

C) Cortisol

D) Leukocytes

E) Glucagon - Answer A) Catecholamines - epi/dopamine

B) Inflammatory cytokines - causes small clots in microcirculation

C) Cortisol - stress hormone

E) Glucagon - stimulates glucose production in liver



Which of the following is NOT a cause of cardiogenic shock?

A) Diastolic or systolic dysfunction

B) Dysrhythmias

C) Myocarditis

,D) Tension pneumothorax

E) Structual abnormalities - Answer D) Tension pneumothorax



This is a possible cause of distributive shock



Cardiac tamponade and ventricular hypertrophy are considered [SYSTOLIC/DIASTOLIC] dysfunction and
can lead to cardiogenic shock. - Answer Diastolic



How does diastolic dysfunction cause cardiogenic shock? - Answer Ineffective filling causes backup of
fluid into lungs

Increased pulmonary pressures causes pulmonary edema and decreased oxygenation



Which structural abnormalities of the heart can cause cardiogenic shock? - Answer Valvular stenosis or
regurgitation



T/F: Cardiomyopathy can be a systolic OR diastolic cause of cardiogenic shock - Answer TRUE



MI, blunt cardiac injury and pulmonary HTN are considered [SYSTOLIC/DIASTOLIC] causes of cardiogenic
shock. - Answer Systolic



How does systolic dysfunction cause cardiogenic shock? - Answer Ineffective forward movement of
blood causes decreased SV and CO



T/F: myocarditis can cause cardiogenic shock - Answer TRUE



What is cardiogenic shock? - Answer When myocardial perfusion is compromised, a decrease in CO, SV,
and BP occur



Which of the following is NOT a manifestation of cardiogenic shock?

A) Tachycardia and hypotensiom

B) Tachypnea and crackles

,C) Widened pulse pressure

D) Increased SVR

E) Cool, clammy skin with pallor and diaphoresis - Answer C) Widened pulse pressure



Cardiogenic shock causes NARROWED pulse pressure



What is absolute hypovolemia in relation to hypovolemic shock? Give some examples. - Answer
Absolute is loss of volume of fluid from the body

Ex. hemorrhage, vomiting, diarrhea, diabetes, and dehydration



What is relative hypovolemia in relation to hypovolemic shock? Give 2 examples. - Answer Relative is
when fluid shifts from where it's supposed to be in the body to where it's not supposed to be. AKA third
spacing



Ex: burns, ascites



Neurogenic, anaphylactic and septic are all types of which shock? - Answer Distributive



What is neurogenic shock? - Answer -Massive vasodilation without compensation

-Leads to pooling of blood, tissue hypoperfusion and impaired metabolism



Which of the following are clinical manifestations of neurogenic shock? Select 3.

A) Pale, cool, clammy skin

B) Hypotension

C) Tachycardia

D) Inability to regulate body temperature

E) Decreased LOC - Answer B) Hypotension

C) Tachycardia

D) Inability to regulate body temperature

, A is cardiogenic and hypovolemic shock.

E is septic, anaphylactic and obstructive shocks



What occurs in the vasculature during anaphylactic shock? - Answer Massive vasodilation and release
of vasoactive mediators = increased capillary permeability

Results in fluid leakage from vascular space into interstitial space



Which of the following skin changes can occur with anaphylactic shock? SATA.

A) Flushing

B) Pruritus

C) Urticaria

D) Angioedema

E) Pallor - Answer A) Flushing

B) Pruritus

C) Urticaria

D) Angioedema



T/F: a pt in anaphylactic shock can be dizzy, have chest pain and/or become incontinent - Answer TRUE



What causes distributive shock? - Answer Physical obstruction to blood flow

Ex. cardiac tamponade, pneumothorax, PE



Where in the body does the initial stage of shock begin? List any manifestations or pertinent
information. - Answer -Occurs at cellular level

-Manifestations not clinically apparent

-Lactic acid buildup begins



What is the compensatory stage of shock? What will the pt's vitals look like? - Answer Clinical
presentation begins to reflect the body's responses

BP is STILL NORMAL but may decrease d/t decreased CO and narrowed pulse pressure

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