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VUSN Pharm 2 Final Exam (Week 12) Questions and Answers 100% Pass $7.99
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VUSN Pharm 2 Final Exam (Week 12) Questions and Answers 100% Pass
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assess for allergies and contraindications, assess for baseline organ function (kidney, liver - LFTs, electrolyte levels), assess for active infection/recent viral infection, monitor CBC for possible bone marrow suppression (Hct, Hgb), admin at same time daily as indicated, ensure drug levels are...

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  • August 16, 2024
  • 10
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • VUSN Pharm 2
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VUSN Pharm 2 Final Exam (Week 12)
assess for allergies and contraindications, assess for baseline organ function (kidney, liver - LFTs,
electrolyte levels), assess for active infection/recent viral infection, monitor CBC for possible bone
marrow suppression (Hct, Hgb), admin at same time daily as indicated, ensure drug levels are drawn just
prior to admin - cyclosporine nursing interventions



benefit of treatment MUST outweigh risks - important thing to remember when considering
immunosuppressant therapy



cyclosporine, prednisone, mycophenolate, IgG - immunosuppressant prototype drugs



organ transplant introduces foreign tissue to body, immune system produces IL-2 (type of lymphokine),
activation of immune system leads to destruction and rejection of foreign tissue - body's response
to organ transplant



IL-2 - specific lymphokine produced by immune system when organ transplant occurs



used to suppress immune system, prevent organ/tissue rejection, prevent tissue destruction,
autoimmune diseases - principals of immunosuppressant therapy



increased risk for infection and neoplasms - risks of immunosuppressant therapy



appropriate, overactive - immunosuppressants minimize effects of which immune responses?

calcineurin inhibitor - cyclosporine class



whole organ transplantation (liver, kidney, heart), autoimmune conditions (rheumatoid arthritis,
psoriasis) - cyclosporine use



inhibits calcineurin (suppresses T-cell proliferation), inhibit production and release of IL-2 -
cyclosporine ETA

, increase levels:

- "azole" antifungals, macrolide antibiotics, Amp-B, grapefruit juice

decrease levels:

- phenytoin, phenobarbital, carbamazepine, rifampin, terbinafine, trimethoprim/sulfamethoxazole -
cyclosporine interactions



nephrotoxicity (75%), infection (75%), hirsutism, HTN, gingival hyperplasia, tumor, anemias (s/t
suppression of bone marrow) - cyclosporine side effects



foods to avoid (don't take w food, decreases absorption), proper med admin (same time daily), warning
s/sx of potential problems - cyclosporine client education



corticosteroid - prednisone class



autoimmune disorders (idiopathic thrombocytopenia purpura), organ transplantation (Renal, liver, bone
marrow, heart), acute inflammatory processes (arthritis caused by acute inflammation, allergic reactions,
asthma) - prednisone use



daily weights, BP, whole blood glucose, check electrolytes (creatinine, sodium, potassium), WBC, monitor
bone density, monitor adrenal insufficiency - prednisone nursing interventions



suppresses migration of leukocytes, inhibits mitosis of lymphocytes, reduces lymphatic system activity,
inhibit production of inflammatory mediators (leukotrienes, prostaglandins, histamines, bradykinins) -
prednisone ETA



skin thinning, infection, bone dissolution, impaired growth, adrenal insufficiency, increased water
retention, polydipsia, increased glucose - prednisone side effects



cytotoxic agent - mycophenolate class

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