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Routes of Drug Administration Complete Solutions

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Routes of Drug Administration Complete Solutions Why is a drug substance incorporated into various dosage forms for administration by alternative routes? To maximize therapeutic response Dosage forms available for different administration routes Brainpower Read More What are the diffe...

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  • August 16, 2024
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  • 2024/2025
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  • Routes of Drug Administration Complete Solution
  • Routes of Drug Administration Complete Solution
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Routes of Drug Administration Complete Solutions
Why is a drug substance incorporated into various dosage forms for administration by alternative
routes?

To maximize therapeutic response

Dosage forms available for different administration routes




Brainpower

Read More

What are the different routes of drug administration?

1. Oral route/Buccal/Sublingual
2. Respiratory Route
3. Nasal
4. Topical Route
5. Ocular
6. Parenteral Route
7. Rectal Route
8. Vaginal

Variation in time of onset of action for different dosage forms




What are the advantages of using the oral route of drug administration?

Most frequently used due to:
1. Simplicity
2. Most convenient
3. Safest mean of drug administration

How does the oral route of drug administration work?

Drug is absorbed by mucosa and various epithelia of G.I tract

What are the disadvantages of the oral route of drug administration?

, 1. Slow onset of action
2. Risk of irregular absorption
3. Destruction of drugs by enzymes and secretions of the G.I. tract

What are the most popular oral dosage forms?

1. Tablets
2. Capsules
3. Suspensions
4. Solutions
5. Emulsions

What are the sublingual and buccal routes of drug administration?

The dosage form is put either under the tongue (sublingual) or in the pouch of the cheek (buccal)

What are the differences between the sublingual and buccal routes of drug administration?

1. Sublingual mucosa is more permeable to buccal one due to higher vascularization and thinner
epithelium - rapid onset of action
2. Sublingual route cannot be used for systemic transmucosal drug administration due to the wash of
the area by saliva, therefore resulting in little time for the drug to be retained at the site of action

What are the general advantages of the sublingual and buccal routes of drug administration?

1. Non-invasive, well-accepted, convenient, accessible
2. The first-pass metabolism by the liver is avoided
3. Drugs can be given to unconscious patients

What are the advantages of the sublingual route of drug administration?

1. Fast onset of drug action due to higher permeability
2. Local action of drugs

What are the advantages of the buccal route of drug administration?

1. Local and systemic effects (oral transmucosal delivery)
2. Suitable for proteins and peptides due to immobile mucosa and extended smooth muscle area
(causes longer retention to the region)

What are the disadvantages of the buccal route of drug administration?

Low drug bioavailability due to low flux of the drug through the buccal mucosa due to low permeability

What are the dosage forms for sublingual and buccal use?

1. Tablets (rapidly disintegrating or bioadhesive)
2. Soft gelatin capsules filled with liquid drug

What is the respiratory route of drug administration?

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