The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney
cells by exporting harmful chemicals against a concentration gradient in an energydependent manner. WThe multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney
cells by exporting harm...
The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine =
3.0, mesothyroxine = 4.0, neothyroxine = 5.0. Of these, which will be absorbed to the
greatest extent from the stomach (pH = 1.0)?
✓ ~~~ neothyroxine
The multi drug resistance proteins (or p-glycoproteins) can protect liver and kidney
cells by exporting harmful chemicals against a concentration gradient in an energy-
dependent manner. What is this called?
✓ ~~~ active transport
Phase II conjugates typically have the following property/properties
✓ ~~~ rapidly excreted in the urine
A drug with a half-life of 2 hours is administered by continuous intravenous infusion.
How long will it take for the drug to reach 50% of its steady state concentration?
✓ ~~~ 2 hours
Caffeine is eliminated primarily by metabolism and with first order kinetics. The half-
life of caffeine varies significantly with individuals, but is on average 5.0 hours. The
volume of distribution is 0.60 L/kg. Joe has a mass of 70 kg and is an average
subject with regard to caffeine pharmacokinetics. He has a regular habit of
consuming a cup of coffee (85 mg of caffeine) at 8 am.
,What is the clearance value (CL) of caffeine in a normal individual?
✓ ~~~ 0.083 L/hr/kg
Which of the following routes is most likely to be affected by the first-pass effect?
✓ ~~~ oral
A drug, given as a 150 mg single dose, results in a peak plasma concentration of 10
ug/mL. The apparent volume of distribution is (rapid distribution and negligible
elimination prior to measuring the peak plasma level):
✓ ~~~ 15 L
Which of the following are routes of drug clearance?
-renal
-sweat
-intestines
✓ ~~~ all of the above
What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes
✓ ~~~ all of the above
What type of receptor is the muscarinic receptor?
, ✓ ~~~ G-protein coupled receptor
For a cholinesterase modified by an organophosphate compound (e.g. soman), what
is the time-dependent dealkylation process called yielding an enzyme refractory
toward reactivation?
✓ ~~~ aging
Muscarinic receptors bind
✓ ~~~ acetylcholine
Which of the following is a clinical use for a muscarinic agonist?
✓ ~~~ "switching on" the urinary tract after surgery
Indirect cholinergic agonists cause
✓ ~~~ inhibition of acetylcholinesterase and a corresponding increase in the synaptic
acetylcholine levels
Which of the following is characteristic of the sympathetic nervous system?
✓ ~~~ responded predominate during physical activity or when experiencing fright
A patient with an acute attack of glaucoma is treated with pilocarpine. The primary
reason for its effectiveness in this condition is its:
✓ ~~~ ability to lower intraocular pressure
Put the following steps in the correct order for neurotransmission at the cholinergic
neuron
, ✓ ~~~ 1. acetylcholine is synthesized from choline and acetyl-CoA
2. acetylcholine is released from storage vesicles into the synaptic cleft
3. acetylcholine is synthesized from choline and acetyl-CoA
4. acetylcholine is degraded by acetylcholinesterase
The autonomic nervous system innervates all of these except
✓ ~~~ skeletal muscle
A soldiers' unit has come under attack with a nerve agent. The symptoms exhibited
are skeletal muscle paralysis, profuse brachial secretions, miosis, bradycardia, and
convulsions. The alarm indicates exposure to an organophosphate. What is the
correct treatment?
✓ ~~~ administer atropine and 2-PAM (pralidoxime)
a study examining how a drug is distributed throughout the body and how the drug is
changed before eliminated is an example of
✓ ~~~ pharmacokinetics
knowing that all three drugs interact with the same receptor, which drug is a
competitive antagonist?
✓ ~~~ C on graph
rate the following drugs labeled 1-4 based on increasing efficacy
✓ ~~~ 2<4<1<3
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ExamArsenal. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.49. You're not tied to anything after your purchase.
