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Test Bank for Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, 9781259641152, Covering Chapters 1-66 | Includes Rationales $17.99   Add to cart

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Test Bank for Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, 9781259641152, Covering Chapters 1-66 | Includes Rationales

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Test Bank for Basic and Clinical Pharmacology, 14th Edition by Bertram G. Katzung, 9781259641152, Covering Chapters 1-66 | Includes Rationales

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  • August 17, 2024
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Test Bank for Basic and Clinical Pharmacology, 14th Edition by
Bertram G. Katzung, 9781259641152, Covering Chapters 1-66
| Includes Rationales


Treatment of superficial fungal infections caused by dermatophytic fungi may be accomplished with
the use of? - ANSWER: 1. topical antifungal agent
2. oral antifungal agent

Examples of Topical Antifungal Agents - ANSWER: clotrimazole, efinaconazole, econazole,
ketoconazole, luliconazole, miconazole, oxiconazole, sertaconazole, sulconazole, ciclopirox olamine,
naftifine, terbinafine, butenafine, and tolnaftate

Examples of Oral Antifungal Agents - ANSWER: griseofulvin, terbinafine, fluconazole, and itraconazole

(AZOLE DERIVATIVES) Topical imidazoles are: - ANSWER: clotrimazole, econazole, ketoconazole,
luliconazole, miconazole, oxiconazole, sertaconazole, and sulconazole

Topical imidazole coverage - ANSWER: wide range of activity against:
Dermatophytes (Epidermophyton, Microsporum, and Trichophyton)

and

Yeasts, including Candida albicans and Pityrosporum orbiculare

Topical imidazole coverage - ANSWER: Dermatophytes and yeasts

Topical imidazoles used in vulvovaginal candidiasis? - ANSWER: Miconazole and Clotrimazole

available as a cream or lotion and as vaginal cream or suppositories - ANSWER: Miconazole

available as a cream or lotion and as vaginal cream and tablets - ANSWER: Clotrimazole

treatment of onychomycosis of the toenails - ANSWER: Efinaconazole (EFIctive for onychomycosis)

How long is the medication for onychomycosis using Eficonazole? - ANSWER: 48 weeks

available as a cream and lotion for topical use - ANSWER: Econazole and Oxiconazole

available as a cream for topical treatment of dermatophytosis and candidiasis and as a shampoo or
foam for the treatment of seborrheic dermatitis. - ANSWER: Ketoconazole

treats dermatophytosis, candidiasis and seborrheic dermatitis? - ANSWER: Ketoconazole

available as a cream - ANSWER: Luliconazole and Sertaconazole

available as a cream or solution - ANSWER: SULConazole (SULotion & Cream)

Why are topical antifungal-corticosteroid fixed combinations have been introduced? - ANSWER: to
provide more rapid symptomatic improvement than an antifungal agent alone.

2 is better than 1.

, Example of topical antifungal-corticosteroid fixed combination? - ANSWER: Clotrimazole-
betamethasone

How frequent do you need to apply certain topical antifungals to clear specific fungal infections? -
ANSWER: 1x- or 2x-daily : clears superficial dermatophyte (for 2-3 wks using any of antifungals)

2x daily : clears seborrheic dermatitis (w/ ketoconzaole)

3x or 4x daily : clears paronychial and intertriginous candidiasis

AE of topical imidazoles? - ANSWER: stinging, pruritus, erythema, and local irritation.

Allergic contact dermatitis is uncommon.

This is a synthetic broad-spectrum antimycotic agent - ANSWER: Ciclopirox olamine

Coverage of Ciclopirox olamine? - ANSWER: activity against dermatophytes, Candida species, and P
orbiculare.

MOA of Ciclopirox olamine? - ANSWER: inhibits the uptake of precursors of macromolecular synthesis

Site of action of Ciclopirox olamine? - ANSWER: probably the fungal cell membrane.

treatment of dermatomycosis, candidiasis, and tinea versicolor - ANSWER: Ciclopirox olamine (1%
cream)

treatment of mild to moderate onychomycosis of fingernails and toenails? - ANSWER: Ciclopirox
olamine (8% cream)

1-2% of the dose is absorbed when applied as a solution at what part of the body? - ANSWER: on the
back under an occlusive dressing.

AE of Ciclopirox olamine? - ANSWER: Pruritus and worsening of clinical disease have been reported.
The potential for allergic contact dermatitis is small.

is the first oxaborole antifungal drug approved for the treatment of toenail onychomycosis. -
ANSWER: Tavaborole

MOA of Tavabarole? - ANSWER: blocks fungal protein synthesis by inhibiting aminoacyl-transfer
ribonucleic acid synthetase.

treatment of toenail onychomycosis - ANSWER: Tavaborole (5% solution) 1x daily for 48 weeks

are allylamines that are highly active against dermatophytes but less active against yeasts. - ANSWER:
Naftifine hydrochloride and terbinafine

Naftifine hydrochloride and terbinafine coverage? - ANSWER: Dermatophytes

Can Naftifine hydrochloride and terbinafine clear infections caused by yeast? - ANSWER: No. It is only
active against Dermatophytes

MOA of Naftifine hydrochloride and terbinafine? - ANSWER: selective inhibition of squalene
epoxidase, a key enzyme for the synthesis of ergosterol

treatment of dermatophytosis? - ANSWER: Naftifine hydrochloride and terbinafine (1% creams) 2x
daily for 1-2 weeks

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