2024 WALDEN 6630
PSYCHOPHARMACOLOGY
MIDTERM STUDY GUIDE EXAM
WITH CORRECT ANSWERS
Two serious medication specific side effects of clozapine include: - CORRECT-
ANSWERSSeizures and Agranulocytosis (leading to frequent and
overwhelming infections)
These two labs must be monitored regularly with use of clozapine: -
CORRECT-ANSWERSWBC and ANC
Due to this medications possible side effects of Agranulocytosis and
subsequent risk for infections, this Atypical Antipsychotic is only used if a
client has not responded to other Antipsychotics: - CORRECT-
ANSWERSclozapine
Cardiac side effects of Atypical Antipsychotics (especially ziprasidone)
include: - CORRECT-ANSWERSProlongation of the QT interval (normal = 0.4-
0.44 seconds)
This Atypical Antipsychotic has the greatest effect on QT interval
prolongation and should not be prescribed for people with arrhythmias: -
CORRECT-ANSWERSziprasidone
Lithium is primarily used in the treatment of: - CORRECT-ANSWERSBipolar
Disorder
The mechanism of action for this medication is unknown but it acts as a
mood stabilizer that can smooth out the "highs and lows": - CORRECT-
ANSWERSLithium
Serotonin regulates - CORRECT-ANSWERSMood, emotion, feeding, and
reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits them
from reuptake of serotonin to increase levels in the synaptic cleft to bind
with postsysnaptic 5HT2 receptors - CORRECT-ANSWERSSSRIs
, First line therapy for MDD due to milder side effect profiles - CORRECT-
ANSWERSSSRIs
Six Common SSRIs - CORRECT-ANSWERScitalopram, escitalopram,
fluoxetine, fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - CORRECT-ANSWERS4-6 weeks
In addition to MDD, SSRIs also treat - CORRECT-ANSWERSChronic Anxiety,
PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include - CORRECT-ANSWERSAnxiety,
insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old -
CORRECT-ANSWERSsuicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination
with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - CORRECT-
ANSWERSSerotonin Syndrome
Excess accumulation of serotonin resulting in overstimulation of the nervous
system - CORRECT-ANSWERSSerotonin Syndrome
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal
include - CORRECT-ANSWERSIrritability, headaches, and insomnia
Medicine specific side effect of citalopram - CORRECT-ANSWERSProlonged
QT interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart
defects - CORRECT-ANSWERSParoxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT-ANSWERSC
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT-
ANSWERSfluoxetine, fluvoxamine, and paroxetine
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