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PHM 431 exam 2 Questions With Complete Solutions
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PHM 431 exam 2 Questions With Complete Solutions
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PHM 431 exam 2 Questions With Complete SolutionsA laboratory rat is tested before and after alprazolam treatment
in the novelty suppressed feeding test and the alprazolam
induced change in feeding latency is recorded. The same rat is
then treated with alcohol for 1 week and retested with
alprazolam in the novelty suppressed feeding test. What would
the anticipated results (and underlying mechanism) be during the
alprazolam retest?
A) an increase in feeding latency because of pharmacodynamic
cross tolerance between ethanol and alprazolam
B) a decrease in feeding latency because of pharmacokinetic
cross tolerance between ethanol and alprazolam
C) an increase in feeding latency because alprazolam induces
cytochrome P450 and alcohol metabolism
D) an increase in feeding latency because alcohol induces
alcohol dehydrogenas Correct Answers A) an increase in
feeding latency because of pharmacodynamic cross tolerance
between ethanol and alprazolam
A loss of function mutation in the gene that encodes the enzyme
glucuronyl transferase will likely cause
A) An increase in the risk of a morphine overdose in patients
having the mutation if they were to receive morphine for pain
relief
B) Accelerated deacetylation of heroin in the brain leading to
higher morphine concentrations and an increased risk for
overdose
,C) Less efficient alcohol metabolism and higher blood alcohol
levels
D) "Bioactivation" of heroin to morphine and increased risk for
morphine overdose Correct Answers A) An increase in the risk
of a morphine overdose in patients having the mutation if they
were to receive morphine for pain relief
A loss of function mutation in the gene that encodes the enzyme
glucuronyl transferase will likely cause
A) An increase in the risk of a morphine overdose in patients
having the mutation if they were to receive morphine for pain
relief
B) Accelerated deacetylation of heroin in the brain leading to
higher morphine concentrations and an increased risk for
overdose
C) Less efficient alcohol metabolism and higher blood alcohol
levels
D) "Bioactivation" of heroin to morphine and increased risk for
morphine overdose Correct Answers A) An increase in the risk
of a morphine overdose in patients having the mutation if they
were to receive morphine for pain relief
a toxic byproduct of alcohol metabolism by CYP2E1 is:
A) acetaldehyde
B) glutathione
C) reactive oxygen species
D) triglycerides Correct Answers C) reactive oxygen species
, a very short duration of action and retrograde amnesia are
actions of which of the following drugs
A) phenobarbital
B) flunitrazepam
C) alcohol
D) chlordiazepoxide Correct Answers B) flunitrazepam
Acomprosate is used to treat alcoholism because it:
A) inhibits aldehyde dehydrogenase in the liver
B) blocks NMDA receptors in the prefrontal cortex
C) inhibits alcohol dehydrogenase in the liver
D) blocks GABA receptors in the amygdala Correct Answers
B) blocks NMDA receptors in prefrontal cortex
activated NFKB moves to ___ to stimulate ___ Correct
Answers moves to nucleus to simulate gene transcription
alcohol and benzodiazepines both act on which brain area to
produce their anti-anxiety actions?
A) ventral tegmental area
B) nucleus accumbens
C) hippocampus
D) amygdala Correct Answers amygdala
alcohol and benzodiazepines both act on which part of the brain
to reduce anxiety
A) lateral hypothalamus
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