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PHM 350 Exam 2 Exam Questions And Answers With Complete Solutions
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PHM 350 Exam 2 Exam Questions And Answers With Complete Solutions
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PHM 350 Exam 2 Exam Questions And Answers WithComplete Solutions
"-pril" drugs reduce BP by:
A - decreasing Na & water excretion leading to reduced blood
volume
B - decreasing the secretion & effect of renin & the
synthesis/effect of angiotensin II
C - reducing Na absorption from the GI tract
D - causing vasodilation by direct action on the vascular smooth
muscle
E - none of the above Correct Answers E - none of the above
"Glifozin" drugs such as canaglifozin (INVOKANA) reduce
plasma glucose by:
A - reducing degradation of GLP1 (incretin) & thus increasing
insulin secretion
B - reducing glucose absorption from GI tract
C - increasing effect of insulin at insulin receptors
D - reducing renal reabsorption of glucose
E - none of the above Correct Answers D - reducing renal
reabsorption of glucose
"Glitazone" drugs:
A - are useful to treat patients with Type 2 diabetes mellitus
B - are useful to treat patients with Type 2 diabetes mellitus
unless insulin resistance has developed
C - are useful as an adjunct (additive treatment) for patients with
Type 1 diabetes mellitus who are receiving insulin
D - are useful for patients with Type 1 diabetes who aren't
receiving insulin
,E - A & C Correct Answers E - A & C
"Loop diuretics" such as furosemid (LASIX) are known as
"potassium wasters" because these diuretics increase K
excretion in the urine. This effect (increased urinal K excretion)
of loop diuretics is caused primarily by:
A - increase Na concentration in the filtrate entering the
collecting duct of the kidney tubules
B - decreased reabsorption of K from the Loop of Henle of each
kidney tubule
C - increased reabsorption of Na from the Loop of Henle of each
kidney tubule
D - increase pH (i.e. decreased acidity) of filtrate caused by loop
diuretics
E - none of the above Correct Answers A - increase Na
concentration in the filtrate entering the collecting duct of the
kidney tubules
A drug initially developed for & effective to treat hypertension
but actually only used therapeutically for the treatment of
erectile dysfunction:
A - minoxidil (ROGAINE)
B - sildenafil (VIAGRA)
C - prazosin (MINPRESS)
D - propranolol (IDERA)
E - A & C Correct Answers B - sildenafil (VIAGRA)
A drug which has anti-inflammatory effects BECAUSE it
increases lipocortin in so called "inflammatory cells:"
A - Prednisone (DELTASONIE)
B - Montelukast (SINGULAIR)
,C - Aspirin
D - Zileuton (ZYFLO)
E - A & C Correct Answers A - Prednisone (DELTASONIE)
A drug which has anti-inflammatory effects by inhibiting
lipoxygenase:
A - prednisone (DELTASONE)
B - zileuton (ZYFLO)
C - celecoxib (CELEBREX)
D - montelukast (SINGULAIR)
E - A & C Correct Answers B - zileuton (ZYFLO)
Acetaminophen (TYLENOL):
A - like aspirin is a useful anti-pyretic drug BECAUSE it
inhibits central cyclooxygenases
B - blocks pain pathways in CNS
C - is a weak anti-inflammatory drug BECAUSE it's
bound/inhibited by peroxide compounds formed at sites of
inflammation
D - alters cellular respiration & upsets blood acid-base balance
E - A & C Correct Answers E - A & C
An anti-hypertensive drug which decreases CO (by actions
within the heart) & which is also an adrenoreceptor antagonist:
A - hydralazine (APRESOLINE)
B - atenolol (TENORMIN)
C - propranolol (INDERAL)
D - prazosin (MINIPRESS)
E - labetalol (NORMODYNE) Correct Answers E - labetalol
(NORMODYNE)
, Angina is often treated with a combination of nitroglycerin
(acutely, i.e. as needed, for ongoing episodes) & a beta1
adrenoreceptor antagonist (chronically, as a prophylactic)
because:
A - both drugs will produce increased blood flow in coronary
blood vessels
B - the adrenoreceptor antagonist will increase myocardial
contractility & thus reduce myocardial oxygen use
C - nitroglycerin will reduce preload & the adrenoreceptor
antagonist will reduce afterload
D - the adrenoreceptor antagonist will reduce the reflex
tachycardia associated with administration of nitroglycerin
E - A & C Correct Answers D - the adrenoreceptor antagonist
will reduce the reflex tachycardia associated with administration
of nitroglycerin
As a non-steroidal anti-inflammatory drug, aspirin:
A - increases activity & effects cyclooxygenase but not of
lipoxygenase
B - decreases phagocytic macrophage migration into tissue at
sites of inflammation
C - used to treat headache & fever because it doesn't cause
irritation of the GI tract
D - used to prevent osteoporosis
E - A & C Correct Answers B - decreases phagocytic
macrophage migration into tissue at sites of inflammation
As a non-steroidal anti-inflammatory drug, aspirin:
A - inhibits the actions of both cyclooxygenase & lipoxygenase
B - increases phagocytic macrophage migration into tissue at
sites of inflammation
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