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MSU PHM 350 exam 2 Questions With Complete Solutions
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MSU PHM 350 exam 2 Questions With Complete Solutions
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MSU PHM 350 exam 2 Questions With Complete Solutions`NSAID's: COX-2 specific inhibitors Correct Answers -
Celecoxib
-Rofecoxib
-Valdecoxib
-target sites of inflammation
-useful to prevent GI problems
a and B adrenergic antagonists Correct Answers -labetalol
-carvedilol
a1 adrenergic antagonist Correct Answers -prazosin
-terazosin
-tamsulosin
a1 adrenergic antagonists mechanism of action/ uses/ side
effects Correct Answers Mechanism:
decrease vascular smooth muscle tone
Vasodilation
decrease TPR , BP
(blocks reflex vasoconstriction)
Uses: Essential Hypertension, CHF, AP, benign prostate
hyperplasia
Side Effects: orthostatic hypertension, dizziness, weakness,
reflex tachycardia, RAS activation
ACE inhibitiors Correct Answers -captopril
,-enalapril
-quinapril
-lisinopril
ACE inhibitors mechanism/ electrolyte disposition (diuretic)
Correct Answers Mechanism:
-blocks plasma Ang II synthesis
-decreases:
aldosterone secretion, Na reabsorption, and K secretion, H2O
reabsorption
Electrolyte dispostion:
Increase Na excretion
Decrease K excretion
Diuretic Effect:
increase urine by <3ml/min
ACE inhibitors- Diuretics Correct Answers -captopril
-enalapril
-quinapril
-lisinopril
Acetaminophen- compared to Asprin Correct Answers -similar
for headache and fever
-very weak anti-inflammatory
-no effect on acid base balance
-no anticoagulant effects
-reduced gastric irritation
-reduced hypersensitivity
-most effective in CNS
,Acetazolamide mechanism of action Correct Answers In
proximal tubule:
CA catlyzes 2 reactions:
-Increase H2O, HCO3, Na retention
-Increase H excretion
Mechanism:
-reduction of CA activity:
-decrease CA= increase H2O, HCO3, Na excretion
-increase H retention
Advantages/ Disadvantages of Acetazolamide Correct Answers
Advantage:
-increase removal of weak acid drugs (asprin when overdose)
-decrease thereputic effectiveness of drug
-increase ecretion of drug in overdose
Disadvantage
-decrease removal of weak base drugs
-increase therapeutic effectiveness of drug
-increase potential for adverse side effects
Analgestic Drugs Correct Answers -anti-inflammatory
-opiate receptor agonists
-local anesthetics
-general anesthetics
Ang II receptor antagonists Correct Answers Losartan
Valsartan
, Anti inflammatory drugs Correct Answers NSAIDS
-cyclooxygenase inhibitors
-lipoxygenase inhibitors
-leukotriene receptor antagonists
(act downstream of phospholipase, reduce activity of COX and
LOX)
SAIDS
-glucocorticoids
-act indirectly on phospholipase
-reduce substrate availability for effects of COX and LOX
Anti- inflammatory Drugs Correct Answers -No interaction
with opiate receptors
-No interaction with local anesthetic processes or general
anesthetics
-No development of tolerance to effect
-No development of dependence on drug
-No addiction to drug
Anti-hyperglycemic compounds Correct Answers -insulin
sensitizers
Arrythmia Correct Answers irregular heart rhythm
Asprin mechanism of action Correct Answers -irreversible
inhibition of cyclooxygenase COX1 and COX2
-inhibition of PG production and effects
-prevention of effecgs of PG metabolites
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