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BIOC 385 Exam 2 || with Accurate Answers 100%.
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What is the difference between the net number of ATP generated by glycolysis from glucose produced by the glycogen phosphorylase enzyme reaction as compared to glucose obtained from the diet? correct answers One less net ATP is generated in glycolysis from dietary glucose as compared to glucose fro...

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  • August 20, 2024
  • 15
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • what is the difference between the net number of a

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BIOC 385 Exam 2 || with Accurate Answers 100%.
What is the difference between the net number of ATP generated by glycolysis from glucose
produced by the glycogen phosphorylase enzyme reaction as compared to glucose obtained from
the diet? correct answers One less net ATP is generated in glycolysis from dietary glucose as
compared to glucose from glycogen.

Part 1: Glycogen metabolism is regulated by both allosteric control and covalent modification.
Circle the best underlined words describing glycogen regulation and record the number. correct
answers Glycogen phosphorylase is regulated by phosphorylation, with the(1) T state / being in
the inactive dephosphorylated conformation.(4) Glucagon signaling stimulates the
phosphorylation of glycogen phosphorylase, resulting in a shift to the (6) active R state
conformation. Glucagon signaling (8) inhibits the activity of glycogen synthase by (9) activating
protein kinase A (PKA).

Part 2: Glycogen metabolism is regulated by both allosteric control and covalent modification.
Circle the best underlined words describing glycogen regulation and record the number. correct
answers Liver glycogen phosphorylase activity is (1) decreased by glucose binding to the
allosteric site, shifting the (3) phosphorylated form of the enzyme into the T state until the
enzyme can be(5) dephosphorylated by insulin signaling. Muscle glycogen phosphorylase is
allosterically(8) activated by low energy charge in the cell and is stimulated by AMP binding.
Moreover, binding of glucose-6P
(9) inhibits muscle glycogen phosphorylase activity.

Starting with glucose imported into a liver cell from the blood, how many ATP are required to
incorporate this imported glucose molecule into liver glycogen. Explain your reasoning. correct
answers 2 ATP;; one ATP needed to generate Glucose-6-P (isomerized to G-1P), and another to
regenerate UTP

Sunflower oil has a melting temperature of -6oC and beef tallow has a melting temperature of
+45oC. What contributes to the ~50oC difference in melting temperature? correct answers Beef
tallow has ~40% palmitate and stearate combined, but sunflower oil has only ~10% combined

Which human disease(s) affecting lipid metabolism is(are) caused by substrate accumulation?
correct answers All of these diseases

(Answers were: Fabry, Tay-sachs, and Niemann-Pick)

Put the following steps in the correct order for absorption of dietary fats. correct answers 1. Eat a
warm lamb chops with lots of gravy
2. fat emulsification by amphipathic bile acids
3. Lipase cleavage of fatty acid in intestines
4. Link three fatty acids to the glycerol in epithelial cells
5. Assembly of large lipoprotein particle in cells
6. Chylomicron export to lymphatic system
7. Chylomicron entry into circulatory system

, Why do fatty acids have to be sequestered by fatty acid binding protein (FABP4) within
adipocytes before being exported to the circulatory system where they are bound to serum
albumin protein? correct answers A correct answer is not provided.

Why does inhibiting 5a-reductase activity block prostate cell growth and induce hair growth?
correct answers Inhibiting 5a-reductase activity decreases dihydrotestosterone production, which
treats both conditions.

Which of the following lipid signaling molecules is derived from a polyunsaturated fatty acid?
correct answers Prostaglandin H2

Calculate the moles of NADH, FADH2, and acetyl-CoA (see structure above). correct answers
10 NADH are generated by b-oxidation of docosanoyl-CoA inside the mitochondrial matrix.

10 FADH2 are generated by b-oxidation of docosanoyl-CoA inside the mitochondrial matrix..

11 acetyl-CoA are generated by b-oxidation of docosanoyl-CoA inside the mitochondrial matrix.

Calculate total amount of ATP (not net ATP) generated from oxidation of docosanoyl-CoA:
correct answers 150

Which KEY enzyme catalyzes the ATP investment reaction required for oxidation of palmitate?
correct answers Fatty acyl-CoA synthetase

What lipid metabolic process is inhibited by hypoglycin A causing ackee Jamaican sickness?
correct answers b-Oxidation of fatty acids

The net fatty acid synthesis reaction for myristate (C14) is: correct answers
7AcetylCoA+6ATP+12NADPH+12H+--> myristate+7CoA+6ADP+6Pi +12NADP+ +5H2O

Lipoproteins are important macromolecular complexes that transport lipids through the
circulatory system, but are also associated with heart disease. Circle true or false for each
statement. correct answers T- LDL particles are "bad" cholesterol because they are associated
with increased heart disease.

F- VLDL particles transport lipids from the intestines into the bile duct of the liver.

F- HDL particles are "good" cholesterol because they are the smallest lipoproteins in serum.

F- Lipoprotein lipase cleaves triacylglycerols in lipoproteins and releases chylomicrons.

T- Statin drugs lower serum LDL levels by stimulating LDL receptor expression on liver cells

Which statements below correctly describe the beneficial drug action of Lipitor? correct answers
Lipitor leads to increased levels of LDL receptors on the surface of liver cells.

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