COX-2 is located in the endoplasmic reticulum where celecoxib is active, whereas COX-1 is
located in the cytoplasm. correct answers COX-1 contains Ile-523, whereas COX-2 contains Val-
523, which permits celecoxib binding.
What controls the bioavailability of arachidonate in the eicosanoid signaling pathway?
GPCR activation of phospholipase A2 leads to cleavage of membrane lipids to produce
arachidonate.
Fatty acid synthase generates arachidonate from palmitate in a reaction requiring NADPH.
Phospholipase A2 cleaves generates prostaglandins by activating arachidonate synthase.
Arachidonate is a polyunsaturated fat derived from the diet and is found in high levels in salmon.
Release of arachidonate from adipose tissue is stimulated by the enzyme hormone-sensitive
lipase. correct answers GPCR activation of phospholipase A2 leads to cleavage of membrane
lipids to produce arachidonate.
Prostaglandins produced by COX-1 are responsible for _________ (1), whereas prostaglandins
produced by the COX-2 enzyme are responsible for ______________(2).
(1) stimulating mucin production
(2) swelling, pain, and fever
(1) stimulating mucin production
(2) causing inflammation in the joints
(1) reducing secretion of HCl in the stomach
(2) causing inflammation in the joints
(1) reducing secretion of HCl in the stomach
(2) swelling, pain, and fever
(1) swelling, pain, and fever
(2) stimulating mucin production correct answers (1) stimulating mucin production
(2) swelling, pain, and fever
, What is thought to be responsible for the increased risk of cardiovascular disease caused by some
selective COX-2 inhibitors?
Activation of prostacyclin synthase, leading to increased blood clot formation.
Inhibition of prostacyclin synthase, leading to increased blood clot formation.
Increased COX-2 activity, leading to increased blood clot formation.
Decreased COX-2 activity, leading to increased blood clot formation.
Decreased COX-1 activity, leading to decreased blood thinning activity. correct answers
Inhibition of prostacyclin synthase, leading to increased blood clot formation.
The activation of glycogen phosphorylase will lead to a(n) __________ in blood glucose
concentrations and is stimulated by the hormone __________.
decrease; glucagon
Activated glucose units are attached to the hydroxyl of which carbon atom in the growing
glycogen chain? correct answers C-3
C-4
C-6
C-1
Order the following steps in glycogen particle synthesis. correct answers A branching enzyme
adds α-1,6 linkages
The glycogen synthase activity of glycogenin forms an α-1,4 glycosidic bond that adds UDP-
glucose to an O-linked glucose disaccharide.
The glycosyltransferase activity of glycogenin adds UDP-glucose to a tyrosine residue in
glycogenin.
Glycogen synthase uses UDP-glucose to form α-1,4 glycosidic bonds that add to the glycogenin
primer
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller FullyFocus. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.49. You're not tied to anything after your purchase.
