Psychiatry-Pharmacology (USMLE)
Exam Questions with Correct Verified
Answers Latest Update (2024/2025)
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1. What nonergot dopamine agonist is used for rescue therapy for
treatment of "off" episodes of akinisia in patients on
dopaminergic therapy? - ANS ✓apomorphine
<i>pre-treatment with antiemetic <b>trimethobenzamide</b>
2. Apomorphine adverse effects (3/6) - ANS ✓QT prolongation
dyskinesias
drowsiness
sweating
hypotension
bruising at the injection site
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3. Name 2 MAOIs that selectively and <b>IRREVERSIBLY</b>
inhibit MAO-B. - ANS ✓deprenyl (selegiline)
<i>mainly used as adjunct to levodopa; allows dose of levodopa to be
reduced
rasagiline
4. Inhibition of DOPA decarboxylase by carbidopa increases what
peripheral metabolite? - ANS ✓3-o-methylDOPA
5. What COMT inhibitor is associated with fulminating hepatic
necrosis? - ANS ✓tolcapone
6. Name 2 COMT inhibitors. - ANS ✓entacapone
tolcapone
7. Amantadine antiparkinsonian MOA - ANS ✓increases synthesis,
release or reuptake of dopamine from the surviving neurons
<i>less efficacious than levodopa and tolerance develops more readily, but
fewer side effects
8. Amantadine systemic adverse effects (3/4) - ANS ✓restlessness
agitation
confusion
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USMLE
peripheral edema
9. What adverse effect is associated with high doses of
amantadine? - ANS ✓acute toxic psychosis
10. What dermatologic adverse effect is associated with
amantadine? - ANS ✓livedo reticularis
11. Drug of choice for Parkinson's disease - ANS ✓levodopa +
carbidopa
12. Are sedative-hypnotics with linear or non-linear dose-
response relationships dangerous? - ANS ✓linear dose-response
curve
<i>increase in dose above that needed for hypnosis may lead to a state of
general anesthesia
higher doses, they may depress respiratory and vasomotor centers in the
medulla, leading to coma and death
13. What drugs are the most widely used anxiolytic drugs? -
ANS ✓benzodiazepines
14. To what receptors do benzodiazepines bind? - ANS
✓GABA<sub>A</sub> receptors
<i>chloride channels
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15. List the subunits that make up the pentameric structure of
the GABA<sub>A</sub> receptor. - ANS ✓alpha-2-beta-2-gamma
<i>binding sites located between adjacent alpha and beta subunits
16. Between which 2 subunits of the GABA<sub>A</sub>
receptor does benzodiazepine bind? - ANS ✓alpha subunit
gamma subunit
<i>increased in frequency of channel opening events
17. Which 2 benzodiazepine receptor subtypes are found in
the CNS? - ANS ✓BZ1
BZ2
18. How does benzodiazepine affect the EC50 for the GABA-
induced Cl- influx? - ANS ✓decreases EC50
19. Name a benzodiazepine receptor antagonist. - ANS
✓flumazenil
20. List 3/5 actions of benzodiazepines. - ANS ✓reduction of
anxiety
sedative and hypnotic actions
Psychiatry-Pharmacology (USMLE)
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