Summary
Case 8 Summary - ILOs
- Course
- Institution
Provides in-depth information about each ILO required for this case
[Show more]
Seller
Follow
guillaumeantem
Content preview
Case 8 SummaryGeneral ILOs:
- To demonstrate knowledge of the elevated presynaptic dopamine function in the
nigrostriatal pathway associated with psychotic symptoms in schizophrenia
- To demonstrate knowledge of the potential risks associated with schizophrenic
symptoms
- To demonstrate knowledge of the reduced dopamine function in prefrontal
cortex associated with cognitive symptoms in schizophrenia
- To demonstrate knowledge of the reduced dopamine function in prefrontal
cortex associated with cognitive symptoms in schizophrenia
- To demonstrate understanding of the nature of delusions and auditory
hallucinations (i.e. positive or psychotic symptoms) in schizophrenia
Dopamine receptors exist within two major families:
D1 – activate adenylyl cyclase
D2 – inhibit adenylyl cyclase
The dopamine system has four major projections:
Nigrostriatal pathway
o Part of the basal ganglia
o Projects to striatum
o Facilitate movement
Mesolimbic pathway
o Rewards pathway
o Begins in the ventral tegmental area (VTA)
o Nucleus accumbens is involved in motivation
Mesocortical pathway
o Originates in VTA
o Travels to frontal lobes
o Reward pathway
Tuberoinfundibular pathway
o Consists of hypothalamus and infundibular region
o Inhibit prolactin release
1
Guillaume Antem – MBChB Y2
, In schizophrenia, there are two abnormalities associated with the dopamine pathways:
Excessive dopamine release in the associative striatum
o Relates to the positive symptoms
o Correlates with good response to antipsychotics
o AKA mesolimbic pathway
Inadequate dopamine release in the prefrontal cortex and ventral striatum
o In DLPFC – cognitive impairment
o In VST – negative symptoms
o AKA mesocortical pathway
In addition to inappropriate dopamine release, glutamate receptor hypofunction (specifically
NMDA receptor) is present in schizophrenia.
2
Guillaume Antem – MBChB Y2
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller guillaumeantem. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.11. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
52510 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now