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MCB4271 - Exam 1 MoAs Study Guide
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MCB4271 - Exam 1 MoAs Study Guidebeta-lactam ring - Answer
PBPs use ____ as a substrate for peptidoglycan synthesis - Answer D-Ala-D-Ala
5 classes of beta lactam antibiotics and where are they derived from? - Answer
Pencillins - mold
Cephalosporins - mold
Carbapenems - bacteria
Monobactams - bacteria
Clavams - bacteria
Penicillin G - Answer delivered intravenously, disc 1928
*narrow spectrum*
Penicillin V - Answer delivered orally, disc 1948
*narrow spectrum*
Ampicillin - Answer disc 1961
*broad spectrum*
Amoxicillin - Answer disc 1972
*broad spectrum*
Methicillin - Answer disc 1960
*narrow spectrum*
Cephalosporin - Answer derived from mold
more effective than Penicillins (less likely to be attacked by penicillinases i.e. more
resistant)
Carbapenems - Answer bacteria
*broad spectrum, effective against 98% of bacteria, reserved for high risk infection*
Monobactams - Answer single 4 member beta-lactam ring
*target Gram -*
Clavams - Answer not potent, mimic B-lactam Ab, trick and saturate B-lactamases
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