Pharmacodynamics of Lovastatin: - Decreases blood cholesterol therefore decreases uptake by modified
lipoproteins.
Decreases LDL, increases HDL
Pregnancy Category... - X
Contraindications: - Hepatic disease
Adverse Effects: - Increased liver enzymes in the blood (monitor these); rhabdomyolysis (muscle
wasting)
What population is most at risk for staton-associated myopathy? - Women over 80
At what time during the day should Lovastatin be taken? - In the evening, possibly bc this is also when
cholesterol synthesis occurs
What dietary considerations should be discussed when taking Lovastatin? - Reduce fat intake. Do not eat
grapefruit (metabolized by P-450)
What labs should be checked to monitor liver damage? - AST, ALT or bilirubin
What lab should be monitored to check for rhabdomyolysis? - Creatinine Kinase
Your pt takes meds for HTN, T2DM, PVD and asthma. He started taking Lovastatin to be treat his
elevated lipid levels. You know this pt should be closely monitored for:
A. Anaphylactic rxns
B. Adverse effects
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