NURS 5315 UTA Exam 2 with Complete Solutions
1. HIV EIA (3rd
generation im-
munoassay)
can use urine, saliva, or serum (most accurate), need
to wait until 12 weeks post exposure to see antibodies,
>99% accurate
4th generation immunoassay- "gold standard"
measures P24 antigen
can test 10...
NURS 5315 UTA Exam 2 with Complete Solutions
1. HIV EIA (3rd can use urine, saliva, or serum (most accurate), need
generation im- to wait until 12 weeks post exposure to see antibodies,
munoassay) >99% accurate
4th generation immunoassay- "gold standard"
measures P24 antigen
can test 10 days post exposure
2. Mast cell Cellular bags of granules located in loose connective
tisssue close to blood vessels. Activation initiates inflam-
matory process.
3. Histamine Causes vasodilation, increases vascular permeability, in-
creases blood flow to the site of injury- causes erythema
and swelling.
4. Cytokines Soluble factors that contribute to the regulation of in-
nate or adaptive resistance by affecting other neighboring
cells. Can be pro-inflammatory or anti-inflammatory. Can
react quickly or be more delayed.
5. Leukotrines Released when mast cells degranulate, prolong the in-
flammatory process. Cause vasodilation, attract neu-
trophils, monocytes, and eosinophils.target of inhibition
for singular.
6. Prostaglandins Released when mast cells degranulate, are produced
by the arachidonic pathway. Cause vasodilation, platelet
aggregation at site of injury, pain, and fever.
7. Chemotactic fac- Biochemical substance that attracts leukocyte to the site
tors of inflammation
8. Neutrophils Predominant leukocyte at work during the early stages of
acute inflammation
9. Monocytes Become macrophages when entering the tissue, respon-
sible for presenting antigens to the CD4 cell which triggers
T-cell immunity and B-cell immunity.
Releases additional cytokines IL1, IL6, TNF.
, NURS 5315 UTA Exam 2 with Complete Solutions
10. Cytokine IL1 Causes fever, activates phagocytes & lymphocytes and
function also increases the release of IL6a
11. Cytokine IL6 Stimulates production of acute phase reactants and pro-
function motes growth and stimulation of RBCs
12. Cytokine TNF Causes fever, increases synthesis of proinflammatory
function proteins by liver, causes muscle wasting, induces throm-
bosis
13. Cytokine growth Promotes production and maturation of neutrophils
factor function
14. Complement Functions include bacterial lysis, vasodilation and in-
creased vascular permeability, triggers mast cell degran-
ulation, chemotaxis, and opsonization.
15. Kinin Converted to bradykinin which is responsible for pain and
chemotaxis, and it increases vascular permeability and
vasodilation.
16. Coagulation cas- Factor XII activates kinin. Function is to form fibrin mesh
cade to stop bleeding and trap micro organisms.
18. COX2 Prostaglandin of arachidonic pathway. Responsible for
pain, fever, renal protection, tissue repair, reproduction
development.
19. COX2 inhibitors- Protect gastric mucosa- prevent ulcers and bleeding. Re-
clinical implica- moved from market r/t cardiac events except for Celebrex.
tions Can impair renal function , monitor labs.
20. Arachidonic Synthesis of prostaglandins
pathway
purpose
21.
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