These notes helped me get into medical school, I completed my a levels at Guildford high school which consistently ranks among the top schools in the UK and is known for their academic rigour. I made these notes as a summary of the power points that we were taught off of.
condensation
proto-oncogenes
· addition base addea
promote normal
L reduced
accessible
expression > heterochromatin
>
-
-
enchromatin cell division but become
oncogenes copies
When mutated
2
inversion > section breaks
away
· -
+
tumor Suppressor
genes
Acetylation
re-attaches reversed
regulate rate of division
acetyl group donated to the histone
cancer is when there is uncontrolled cell growth leading to
from an acetyl coenzyme
the formation of a tumor
by permanent activation of an
DNA is
negatively charged
·
oncogene or
hypermethylation of the promotor region of
↓ ↑ positive
Acetylation =
charge
-
a tumor suppressor gene .
-
.: 4 attraction : ↓ transcription
RNA interference oestrogen diffuses easily into
↓
Meth lation 000000000000 the cell
Y SiRNA
more oestrogen produced after "II
000000000000
methyl group added to
cytosine molecules short double-stranded oestrogen binds to receptors
likely
V
more
·
:
menopause
blocks transcription factors from conformational
o
causing a
-
becomes unwound and pairs to
to
get
·
cancer
binding : ↓ transcription complimentary mRNA
segment
change in the
binding site
attracts protein that induces on the transcription factor
-
deacetylation ·
the complex cleaves to prevent
translation activating it. the transcription
Stem cells silencing it
totipotent zygote/early embryo any cell
, ,
miRNA
·D factor binds to the promotor
region of the DNA activating
pluripotent , cell but placenta
·
acts similarly
any
-
comes from RNA that
transcription
multipotent , limited differentiation
·
↳
has unintentionally folded
omnipotent ,
only a
single cell
type
back on itself
&-
S
Y
-SE
V
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller anastazjaohearn. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $4.50. You're not tied to anything after your purchase.
