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NURS660-EXAM4 Questions & 100% correct Answers- Latest Test | Graded A+ | Passed

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Methadone is a _____ mu opioid receptor agonist. Side effects include _____ and _____ ;-- Full. Constipation, sedation. Buprenorphine (suboxone) is a _____ at the opioid receptor. Often combined with naltrexone to prevent abuse ;-- Partial agonist Naloxone (Narcan) is a mu receptor _____ . ...

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  • August 26, 2024
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NURS660-EXAM4 Questions & 100% correct
Answers- Latest Test | Graded A+ | Passed
Methadone is a _____ mu opioid receptor agonist. Side effects include _____ and _____

✓ ;-- Full. Constipation, sedation.



Buprenorphine (suboxone) is a _____ at the opioid receptor. Often combined with naltrexone

to prevent abuse

✓ ;-- Partial agonist



Naloxone (Narcan) is a mu receptor _____ . it has little effect compared to buprenorphine

(usually 1:4 ratio).

✓ ;-- Antagonist



When buprenorphine/naloxone is injected or inhaled the ANTAGONIST effects of _____

dominate and w/d symptoms are precipitated

✓ ;-- Naloxone



Overdose is much more likely with ____ than _____

✓ ;-- Methadone (full agonist) > buprenorphine (partial agonist)



Extended-release buprenorphine can be dosed ____

✓ ;-- Subcutaneous once per month after demonstrating tolerability for 1-week oral dosing



Naltrexone (ReVia) is a Mu receptor antagonist. Consideration before starting _____


26/08/2024 | © Copyright- This work may not be copied for profit.

, Excellence is key | 2024/2025 ~Page |2


✓ ;-- Opiate free 7-10d or w/d symptoms



Naltrexone (ReVia) is available as once-monthly injection. How does it work? ____

✓ ;-- Blocks Mu receptors to prevent euphoric effects if patient relapses. Helps with abstinence
to eliminate reward



3 meds FDA approved for AUD

✓ ;-- Disufiram, Acamprosate, Naltrexone. Off-label = Gabapentin and topiramate



NIAAA defines 'At risk' for men _____. Women _____. Above age 65 _____

✓ ;-- Men= 4/day, 14/week. Women= 3/day, 7/week. >65= same as for women



Binge drinking for men _____, for women=_____

✓ ;-- Men= 5 in 2 hrs. Women= 4 in 2 hrs



Describe transmitters involved in etOH withdrawal

✓ ;-- Over time alcoholics up-regulate Glutamate to match the excess GABA. When there's a
withdrawal there is a relative excess



Timeline of alcohol withdrawal

✓ ;-- Minor- within 36 hrs. Seizures- 1-2d. Hallucinosis- 1-2d. DT's- 1-4d



Disulfiram (Antabuse) adverse effects

✓ ;-- Metallic taste, hepatotoxicity, optic neuritis, peripheral neuropathy. (causes physically ill
from buildup of acetaldehyde)




26/08/2024 | © Copyright- This work may not be copied for profit.

, Excellence is key | 2024/2025 ~Page |3


Acamprosate (Camral), how does it work?

✓ ;-- Dosed 3x's/day. Cleared renally. Glutamate receptor modulator.



How does naltrexone (ReVia) work in alcohol cessation.

✓ ;-- Blocks opioid Mu receptors and secondary dopamine (reduce pleasure and cravings)



Naltrexone extended release (Vivitrol) adverse effects

✓ ;-- Nausea, vomiting, precipitated opioid withdrawal, depression, elevated LFT's



Mild withdrawal starts within ____ hours and resolve in _____. These include:

✓ ;-- 6-24. resolve 1-2 days. Tremor, anxiety, headache, insomnia, GI upset



Hallucinations start within _____ and resolve in _____

✓ ;-- 12-24 hrs, resolve 1-2days



Moderate and Severe withdrawal starts within _____ and lasts _____

✓ ;-- 1-3 days, can last 5-7



DT's start _____ and can last _____

✓ ;-- 3-4 days and last 2-3 days



Triad of Wernicke's

✓ ;-- Encephalopathy, oculomotor dysfunction, gait ataxia (often progresses to Korsakoff
syndrome)




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